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Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

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JournalPhysical chemistry chemical physics : PCCP
DateAccepted/In press - 15 Aug 2016
DateE-pub ahead of print - 15 Aug 2016
DatePublished (current) - 28 Sep 2016
Issue number36
Volume18
Number of pages7
Pages (from-to)24905-24911
Early online date15/08/16
Original languageEnglish

Abstract

The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4 % net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future

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© The Royal Society of Chemistry, 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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