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From the same journal

Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis

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Author(s)

  • Romy Schmidt
  • Martin Fulda
  • Melanie Paul
  • Max Anders
  • Frederic Plum
  • Daniel Weits
  • Monika Kosmacz
  • Tony Larson
  • Ian Alexander Graham
  • Gerrit Beemster
  • Francesco Licausi
  • Peter Gelgenberger
  • Jos Schippers
  • Joost T. van Dongen

Department/unit(s)

Publication details

JournalProceedings of the National Academy of Sciences of the United States of America
DateAccepted/In press - 5 Nov 2018
DateE-pub ahead of print - 3 Dec 2018
DatePublished (current) - 18 Dec 2018
Issue number51
Volume115
Number of pages10
Pages (from-to)E12101–E12110
Early online date3/12/18
Original languageEnglish

Abstract

Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of the acyl-CoA pool and (ii) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy.

Bibliographical note

© 2018 the Author(s)

    Research areas

  • ACBP, Acyl-CoA, ERFVII, Integrative signaling, Low-oxygen stress, Diazepam Binding Inhibitor/metabolism, Signal Transduction, Arabidopsis/genetics, Stress, Physiological, Adenosine Triphosphate/metabolism, Oxygen/metabolism, Cell Hypoxia, Models, Biological, Acyl Coenzyme A/metabolism, Gene Expression Regulation, Plant, Arabidopsis Proteins/metabolism

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