Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky; Héctor A Velásquez García; John J. Spinelli; Patrick Gaffney; Karin E. Smedby; Rosalind Ramsey-Goldman; Sophia S Wang; Hans-Olov Adami; Demetrius Albanes; Emanuele Angelucci; Stephen M Ansell; Yan W Asmann; Nikolaus Becker; Yolanda Benavente; Sonja I Berndt; Kimberly A Bertrand; Brenda M Birmann; Heiner Boeing; Paolo Boffetta; Paige M. Bracci; Paul Brennan; Angela R Brooks-Wilson; James R. Cerhan; Stephen J. Chanock; Jacqueline Clavel; Lucia Conde; Karen H Cotenbader; David G Cox; Wendy Cozen; Simon Crouch; Anneclaire J. De Roos; Silvia de Sanjose; Simonetta Di Lollo; W Ryan Diver; Ahmet Dogan; Lenka Foretova; Hervé Ghesquières; Graham G. Giles; Bengt Glimelius; Thomas M Habermann; Corinne Haioun; Patricia Hartge; Henrik Hjalgrim; Theodore R. Holford; Elizabeth A. Holly; Rebecca D Jackson; Rudolph Kaaks; Eleanor Kane; Rachel S Kelly; Robert J Klein; Peter Kraft; Anne Kricker; Qing Lan; Charles Lawrence; Mark Liebow; Tracy Lightfoot; Brian K Link; Marc Maynadie; James D McKay; Mads Melbye; Thierry Jo Molina; Alain Monnereau; Lindsay M. Morton; Alexandra Nieters; Kari E North; Anne J. Novak; Kenneth Offit; Mark P Purdue; Marco Rais; Jacques Riby; Eve Roman; Nathaniel Rothman; Gilles Salles; Gianluca Severi; Richard K. Severson; Christine F. Skibola; Susan L. Slager; Martyn T Smith; Melissa C Southey; Anthony Staines; Lauren R Teras; Carrie A Thompson; Hervé Tilly; Lesley F Tinker; Anne Tjonneland; Jenny Turner; Claire M. Vajdic; Roel C H Vermeulen; Joseph Vijai; Paolo Vineis; Jarmo Virtamo; Zhaoming Wang; Stephanie Weinstein; Thomas E Witzig; Andrew Zelenetz; Anne Zeleniuch-Jacquotte; Yawei Zhang; Tongzhang Zheng; Mariagrazia Zucca; Ann E Clarke; Alexandra Gwen Smith

doi:10.1136/lupus-2016-000187

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky, Héctor A Velásquez García, John J. Spinelli, Patrick Gaffney, Karin E. Smedby, Rosalind Ramsey-Goldman, Sophia S Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci, Stephen M Ansell, Yan W Asmann, Nikolaus Becker, Yolanda Benavente, Sonja I Berndt, Kimberly A Bertrand, Brenda M Birmann, Heiner Boeing, Paolo Boffetta, Paige M. BracciPaul Brennan, Angela R Brooks-Wilson, James R. Cerhan, Stephen J. Chanock, Jacqueline Clavel, Lucia Conde, Karen H Cotenbader, David G Cox, Wendy Cozen, Simon Crouch, Anneclaire J. De Roos, Silvia de Sanjose, Simonetta Di Lollo, W Ryan Diver, Ahmet Dogan, Lenka Foretova, Hervé Ghesquières, Graham G. Giles, Bengt Glimelius, Thomas M Habermann, Corinne Haioun, Patricia Hartge, Henrik Hjalgrim, Theodore R. Holford, Elizabeth A. Holly, Rebecca D Jackson, Rudolph Kaaks, Eleanor Kane, Rachel S Kelly, Robert J Klein, Peter Kraft, Anne Kricker, Qing Lan, Charles Lawrence, Mark Liebow, Tracy Lightfoot, Brian K Link, Marc Maynadie, James D McKay, Mads Melbye, Thierry Jo Molina, Alain Monnereau, Lindsay M. Morton, Alexandra Nieters, Kari E North, Anne J. Novak, Kenneth Offit, Mark P Purdue, Marco Rais, Jacques Riby, Eve Roman, Nathaniel Rothman, Gilles Salles, Gianluca Severi, Richard K. Severson, Christine F. Skibola, Susan L. Slager, Martyn T Smith, Melissa C Southey, Anthony Staines, Lauren R Teras, Carrie A Thompson, Hervé Tilly, Lesley F Tinker, Anne Tjonneland, Jenny Turner, Claire M. Vajdic, Roel C H Vermeulen, Joseph Vijai, Paolo Vineis, Jarmo Virtamo, Zhaoming Wang, Stephanie Weinstein, Thomas E Witzig, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Mariagrazia Zucca, Ann E Clarke, Alexandra Gwen Smith

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.

Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.

Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.

Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Original language	English
Article number	e000187
Number of pages	6
Journal	Lupus science & medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1136/lupus-2016-000187
Publication status	Published - 1 Oct 2017

Keywords

Journal Article

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10.1136/lupus-2016-000187

e000187.fullFinal published version, 535 KBLicence: CC BY-NC

Cite this

Bernatsky, S., Velásquez García, H. A., Spinelli, J. J., Gaffney, P., Smedby, K. E., Ramsey-Goldman, R., Wang, S. S., Adami, H.-O., Albanes, D., Angelucci, E., Ansell, S. M., Asmann, Y. W., Becker, N., Benavente, Y., Berndt, S. I., Bertrand, K. A., Birmann, B. M., Boeing, H., Boffetta, P., ... Smith, A. G. (2017). Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus science & medicine, 4(1), Article e000187. https://doi.org/10.1136/lupus-2016-000187

@article{1269b529f360423492d4529552ed855d,

title = "Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma",

abstract = "Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.",

keywords = "Journal Article",

author = "Sasha Bernatsky and {Vel{\'a}squez Garc{\'i}a}, {H{\'e}ctor A} and Spinelli, {John J.} and Patrick Gaffney and Smedby, {Karin E.} and Rosalind Ramsey-Goldman and Wang, {Sophia S} and Hans-Olov Adami and Demetrius Albanes and Emanuele Angelucci and Ansell, {Stephen M} and Asmann, {Yan W} and Nikolaus Becker and Yolanda Benavente and Berndt, {Sonja I} and Bertrand, {Kimberly A} and Birmann, {Brenda M} and Heiner Boeing and Paolo Boffetta and Bracci, {Paige M.} and Paul Brennan and Brooks-Wilson, {Angela R} and Cerhan, {James R.} and Chanock, {Stephen J.} and Jacqueline Clavel and Lucia Conde and Cotenbader, {Karen H} and Cox, {David G} and Wendy Cozen and Simon Crouch and {De Roos}, {Anneclaire J.} and {de Sanjose}, Silvia and {Di Lollo}, Simonetta and Diver, {W Ryan} and Ahmet Dogan and Lenka Foretova and Herv{\'e} Ghesqui{\`e}res and Giles, {Graham G.} and Bengt Glimelius and Habermann, {Thomas M} and Corinne Haioun and Patricia Hartge and Henrik Hjalgrim and Holford, {Theodore R.} and Holly, {Elizabeth A.} and Jackson, {Rebecca D} and Rudolph Kaaks and Eleanor Kane and Kelly, {Rachel S} and Klein, {Robert J} and Peter Kraft and Anne Kricker and Qing Lan and Charles Lawrence and Mark Liebow and Tracy Lightfoot and Link, {Brian K} and Marc Maynadie and McKay, {James D} and Mads Melbye and Molina, {Thierry Jo} and Alain Monnereau and Morton, {Lindsay M.} and Alexandra Nieters and North, {Kari E} and Novak, {Anne J.} and Kenneth Offit and Purdue, {Mark P} and Marco Rais and Jacques Riby and Eve Roman and Nathaniel Rothman and Gilles Salles and Gianluca Severi and Severson, {Richard K.} and Skibola, {Christine F.} and Slager, {Susan L.} and Smith, {Martyn T} and Southey, {Melissa C} and Anthony Staines and Teras, {Lauren R} and Thompson, {Carrie A} and Herv{\'e} Tilly and Tinker, {Lesley F} and Anne Tjonneland and Jenny Turner and Vajdic, {Claire M.} and Vermeulen, {Roel C H} and Joseph Vijai and Paolo Vineis and Jarmo Virtamo and Zhaoming Wang and Stephanie Weinstein and Witzig, {Thomas E} and Andrew Zelenetz and Anne Zeleniuch-Jacquotte and Yawei Zhang and Tongzhang Zheng and Mariagrazia Zucca and Clarke, {Ann E} and Smith, {Alexandra Gwen}",

year = "2017",

month = oct,

day = "1",

doi = "10.1136/lupus-2016-000187",

language = "English",

volume = "4",

journal = "Lupus science & medicine",

issn = "2053-8790",

publisher = "BMJ",

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Bernatsky, S, Velásquez García, HA, Spinelli, JJ, Gaffney, P, Smedby, KE, Ramsey-Goldman, R, Wang, SS, Adami, H-O, Albanes, D, Angelucci, E, Ansell, SM, Asmann, YW, Becker, N, Benavente, Y, Berndt, SI, Bertrand, KA, Birmann, BM, Boeing, H, Boffetta, P, Bracci, PM, Brennan, P, Brooks-Wilson, AR, Cerhan, JR, Chanock, SJ, Clavel, J, Conde, L, Cotenbader, KH, Cox, DG, Cozen, W, Crouch, S, De Roos, AJ, de Sanjose, S, Di Lollo, S, Diver, WR, Dogan, A, Foretova, L, Ghesquières, H, Giles, GG, Glimelius, B, Habermann, TM, Haioun, C, Hartge, P, Hjalgrim, H, Holford, TR, Holly, EA, Jackson, RD, Kaaks, R, Kane, E, Kelly, RS, Klein, RJ, Kraft, P, Kricker, A, Lan, Q, Lawrence, C, Liebow, M, Lightfoot, T, Link, BK, Maynadie, M, McKay, JD, Melbye, M, Molina, TJ, Monnereau, A, Morton, LM, Nieters, A, North, KE, Novak, AJ, Offit, K, Purdue, MP, Rais, M, Riby, J, Roman, E, Rothman, N, Salles, G, Severi, G, Severson, RK, Skibola, CF, Slager, SL, Smith, MT, Southey, MC, Staines, A, Teras, LR, Thompson, CA, Tilly, H, Tinker, LF, Tjonneland, A, Turner, J, Vajdic, CM, Vermeulen, RCH, Vijai, J, Vineis, P, Virtamo, J, Wang, Z, Weinstein, S, Witzig, TE, Zelenetz, A, Zeleniuch-Jacquotte, A, Zhang, Y, Zheng, T, Zucca, M, Clarke, AE & Smith, AG 2017, 'Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma', Lupus science & medicine, vol. 4, no. 1, e000187. https://doi.org/10.1136/lupus-2016-000187

TY - JOUR

T1 - Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

AU - Bernatsky, Sasha

AU - Velásquez García, Héctor A

AU - Spinelli, John J.

AU - Gaffney, Patrick

AU - Smedby, Karin E.

AU - Ramsey-Goldman, Rosalind

AU - Wang, Sophia S

AU - Adami, Hans-Olov

AU - Albanes, Demetrius

AU - Angelucci, Emanuele

AU - Ansell, Stephen M

AU - Asmann, Yan W

AU - Becker, Nikolaus

AU - Benavente, Yolanda

AU - Berndt, Sonja I

AU - Bertrand, Kimberly A

AU - Birmann, Brenda M

AU - Boeing, Heiner

AU - Boffetta, Paolo

AU - Bracci, Paige M.

AU - Brennan, Paul

AU - Brooks-Wilson, Angela R

AU - Cerhan, James R.

AU - Chanock, Stephen J.

AU - Clavel, Jacqueline

AU - Conde, Lucia

AU - Cotenbader, Karen H

AU - Cox, David G

AU - Cozen, Wendy

AU - Crouch, Simon

AU - De Roos, Anneclaire J.

AU - de Sanjose, Silvia

AU - Di Lollo, Simonetta

AU - Diver, W Ryan

AU - Dogan, Ahmet

AU - Foretova, Lenka

AU - Ghesquières, Hervé

AU - Giles, Graham G.

AU - Glimelius, Bengt

AU - Habermann, Thomas M

AU - Haioun, Corinne

AU - Hartge, Patricia

AU - Hjalgrim, Henrik

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Jackson, Rebecca D

AU - Kaaks, Rudolph

AU - Kane, Eleanor

AU - Kelly, Rachel S

AU - Klein, Robert J

AU - Kraft, Peter

AU - Kricker, Anne

AU - Lan, Qing

AU - Lawrence, Charles

AU - Liebow, Mark

AU - Lightfoot, Tracy

AU - Link, Brian K

AU - Maynadie, Marc

AU - McKay, James D

AU - Melbye, Mads

AU - Molina, Thierry Jo

AU - Monnereau, Alain

AU - Morton, Lindsay M.

AU - Nieters, Alexandra

AU - North, Kari E

AU - Novak, Anne J.

AU - Offit, Kenneth

AU - Purdue, Mark P

AU - Rais, Marco

AU - Riby, Jacques

AU - Roman, Eve

AU - Rothman, Nathaniel

AU - Salles, Gilles

AU - Severi, Gianluca

AU - Severson, Richard K.

AU - Skibola, Christine F.

AU - Slager, Susan L.

AU - Smith, Martyn T

AU - Southey, Melissa C

AU - Staines, Anthony

AU - Teras, Lauren R

AU - Thompson, Carrie A

AU - Tilly, Hervé

AU - Tinker, Lesley F

AU - Tjonneland, Anne

AU - Turner, Jenny

AU - Vajdic, Claire M.

AU - Vermeulen, Roel C H

AU - Vijai, Joseph

AU - Vineis, Paolo

AU - Virtamo, Jarmo

AU - Wang, Zhaoming

AU - Weinstein, Stephanie

AU - Witzig, Thomas E

AU - Zelenetz, Andrew

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Yawei

AU - Zheng, Tongzhang

AU - Zucca, Mariagrazia

AU - Clarke, Ann E

AU - Smith, Alexandra Gwen

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

AB - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

KW - Journal Article

U2 - 10.1136/lupus-2016-000187

DO - 10.1136/lupus-2016-000187

M3 - Article

C2 - 29214033

SN - 2053-8790

VL - 4

JO - Lupus science & medicine

JF - Lupus science & medicine

IS - 1

M1 - e000187

ER -