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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

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Author(s)

  • Sasha Bernatsky
  • Héctor A Velásquez García
  • John J. Spinelli
  • Patrick Gaffney
  • Karin E. Smedby
  • Rosalind Ramsey-Goldman
  • Sophia S Wang
  • Hans-Olov Adami
  • Demetrius Albanes
  • Emanuele Angelucci
  • Stephen M Ansell
  • Yan W Asmann
  • Nikolaus Becker
  • Yolanda Benavente
  • Sonja I Berndt
  • Kimberly A Bertrand
  • Brenda M Birmann
  • Heiner Boeing
  • Paolo Boffetta
  • Paige M. Bracci
  • Paul Brennan
  • Angela R Brooks-Wilson
  • James R. Cerhan
  • Stephen J. Chanock
  • Jacqueline Clavel
  • Lucia Conde
  • Karen H Cotenbader
  • David G Cox
  • Wendy Cozen
  • Anneclaire J. De Roos
  • Silvia de Sanjose
  • Simonetta Di Lollo
  • W Ryan Diver
  • Ahmet Dogan
  • Lenka Foretova
  • Hervé Ghesquières
  • Graham G. Giles
  • Bengt Glimelius
  • Thomas M Habermann
  • Corinne Haioun
  • Patricia Hartge
  • Henrik Hjalgrim
  • Theodore R. Holford
  • Elizabeth A. Holly
  • Rebecca D Jackson
  • Rudolph Kaaks
  • Rachel S Kelly
  • Robert J Klein
  • Peter Kraft
  • Anne Kricker
  • Qing Lan
  • Charles Lawrence
  • Mark Liebow
  • Brian K Link
  • Marc Maynadie
  • James D McKay
  • Mads Melbye
  • Thierry Jo Molina
  • Alain Monnereau
  • Lindsay M. Morton
  • Alexandra Nieters
  • Kari E North
  • Anne J. Novak
  • Kenneth Offit
  • Mark P Purdue
  • Marco Rais
  • Jacques Riby
  • Nathaniel Rothman
  • Gilles Salles
  • Gianluca Severi
  • Richard K. Severson
  • Christine F. Skibola
  • Susan L. Slager
  • Martyn T Smith
  • Melissa C Southey
  • Anthony Staines
  • Lauren R Teras
  • Carrie A Thompson
  • Hervé Tilly
  • Lesley F Tinker
  • Anne Tjonneland
  • Jenny Turner
  • Claire M. Vajdic
  • Roel C H Vermeulen
  • Joseph Vijai
  • Paolo Vineis
  • Jarmo Virtamo
  • Zhaoming Wang
  • Stephanie Weinstein
  • Thomas E Witzig
  • Andrew Zelenetz
  • Anne Zeleniuch-Jacquotte
  • Yawei Zhang
  • Tongzhang Zheng
  • Mariagrazia Zucca
  • Ann E Clarke

Department/unit(s)

Publication details

JournalLupus science & medicine
DateAccepted/In press - 30 Nov 2016
DatePublished (current) - 1 Oct 2017
Issue number1
Volume4
Number of pages6
Original languageEnglish

Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.

Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.

Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.

Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

    Research areas

  • Journal Article

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