Lytic Polysaccharide Monooxygenases in Biomass Conversion

Glyn R. Hemsworth; Esther M. Johnston; Gideon J. Davies; Paul H. Walton

doi:10.1016/j.tibtech.2015.09.006

Lytic Polysaccharide Monooxygenases in Biomass Conversion

Glyn R. Hemsworth^*, Esther M. Johnston, Gideon J. Davies, Paul H. Walton

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The derivation of second-generation biofuels from non-edible biomass is viewed as crucial for establishing a sustainable bio-based economy for the future. The inertness of lignocellulosic biomass makes its breakdown for conversion into fuels and other compounds a challenge. Enzyme cocktails can be utilized in the bio-refinery for lignocellulose deconstruction but until recently their costs were regarded as high. Lytic polysaccharide monooxygenases (LPMOs) offer tremendous promise for further process improvements owing to their ability to boost the activity of biomass-degrading enzyme consortia. Combining data from multiple disciplines, progress has been made in understanding the biochemistry of LPMOs. We review the academic literature in this area and highlight some of the key questions that remain.

Original language	English
Pages (from-to)	747-761
Number of pages	15
Journal	TRENDS IN BIOTECHNOLOGY
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/j.tibtech.2015.09.006
Publication status	Published - Dec 2015

Bibliographical note

Keywords

Biomass conversion
Chitin
Lignocellulose
Lytic polysaccharide monooxygenase
Starch

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10.1016/j.tibtech.2015.09.006

Cite this

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title = "Lytic Polysaccharide Monooxygenases in Biomass Conversion",

abstract = "The derivation of second-generation biofuels from non-edible biomass is viewed as crucial for establishing a sustainable bio-based economy for the future. The inertness of lignocellulosic biomass makes its breakdown for conversion into fuels and other compounds a challenge. Enzyme cocktails can be utilized in the bio-refinery for lignocellulose deconstruction but until recently their costs were regarded as high. Lytic polysaccharide monooxygenases (LPMOs) offer tremendous promise for further process improvements owing to their ability to boost the activity of biomass-degrading enzyme consortia. Combining data from multiple disciplines, progress has been made in understanding the biochemistry of LPMOs. We review the academic literature in this area and highlight some of the key questions that remain.",

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AU - Hemsworth, Glyn R.

AU - Johnston, Esther M.

AU - Davies, Gideon J.

AU - Walton, Paul H.

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AB - The derivation of second-generation biofuels from non-edible biomass is viewed as crucial for establishing a sustainable bio-based economy for the future. The inertness of lignocellulosic biomass makes its breakdown for conversion into fuels and other compounds a challenge. Enzyme cocktails can be utilized in the bio-refinery for lignocellulose deconstruction but until recently their costs were regarded as high. Lytic polysaccharide monooxygenases (LPMOs) offer tremendous promise for further process improvements owing to their ability to boost the activity of biomass-degrading enzyme consortia. Combining data from multiple disciplines, progress has been made in understanding the biochemistry of LPMOs. We review the academic literature in this area and highlight some of the key questions that remain.

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KW - Chitin

KW - Lignocellulose

KW - Lytic polysaccharide monooxygenase

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DO - 10.1016/j.tibtech.2015.09.006

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Lytic Polysaccharide Monooxygenases in Biomass Conversion

Abstract

Bibliographical note

Keywords

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