Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

TY - JOUR

T1 - Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

AU - Couturier, Marie

AU - Ladevèze, Simon

AU - Sulzenbacher, Gerlind

AU - Ciano, Luisa

AU - Fanuel, Mathieu

AU - Moreau, Céline

AU - Villares, Ana

AU - Cathala, Bernard

AU - Chaspoul, Florence

AU - Herpoël-Gimbert, Isabelle

AU - Grisel, Sacha

AU - Haon, Mireille

AU - Lenfant, Nicolas

AU - Rogniaux, Hélène

AU - Ropartz, David

AU - Davies, Gideon

AU - Rosso, Marie-Noëlle

AU - Walton, Paul H.

AU - Henrissat, Bernard

AU - Berrin, Jean-Guy

AU - Labourel, Aurore

AU - Frandsen, Kristian E

N1 - © 2018, Springer Nature. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-ef-fective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans—a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxida-tive cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.

AB - Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-ef-fective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans—a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxida-tive cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.

UR - http://www.scopus.com/inward/record.url?scp=85042099460&partnerID=8YFLogxK

U2 - 10.1038/nchembio.2558

DO - 10.1038/nchembio.2558

M3 - Article

SN - 1552-4450

VL - 14

SP - 306

EP - 310

JO - NATURE CHEMICAL BIOLOGY

JF - NATURE CHEMICAL BIOLOGY

IS - 3

ER -