Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Marie Couturier; Simon Ladevèze; Gerlind Sulzenbacher; Luisa Ciano; Mathieu Fanuel; Céline Moreau; Ana Villares; Bernard Cathala; Florence Chaspoul; Isabelle Herpoël-Gimbert; Sacha Grisel; Mireille Haon; Nicolas Lenfant; Hélène Rogniaux; David Ropartz; Gideon Davies; Marie-Noëlle Rosso; Paul H. Walton; Bernard Henrissat; Jean-Guy Berrin; Aurore Labourel; Kristian E Frandsen

doi:10.1038/nchembio.2558

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Marie Couturier, Simon Ladevèze, Gerlind Sulzenbacher, Luisa Ciano, Mathieu Fanuel, Céline Moreau, Ana Villares, Bernard Cathala, Florence Chaspoul, Isabelle Herpoël-Gimbert, Sacha Grisel, Mireille Haon, Nicolas Lenfant, Hélène Rogniaux, David Ropartz, Gideon Davies, Marie-Noëlle Rosso, Paul H. Walton, Bernard Henrissat, Jean-Guy BerrinAurore Labourel, Kristian E Frandsen

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-ef-fective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans—a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxida-tive cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.

Original language	English
Pages (from-to)	306-310
Journal	NATURE CHEMICAL BIOLOGY
Volume	14
Issue number	3
Early online date	29 Jan 2018
DOIs	https://doi.org/10.1038/nchembio.2558
Publication status	Published - 1 Mar 2018

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© 2018, Springer Nature. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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Cite this

Couturier, M., Ladevèze, S., Sulzenbacher, G., Ciano, L., Fanuel, M., Moreau, C., Villares, A., Cathala, B., Chaspoul, F., Herpoël-Gimbert, I., Grisel, S., Haon, M., Lenfant, N., Rogniaux, H., Ropartz, D., Davies, G., Rosso, M.-N., Walton, P. H., Henrissat, B., ... Frandsen, K. E. (2018). Lytic xylan oxidases from wood-decay fungi unlock biomass degradation. NATURE CHEMICAL BIOLOGY, 14(3), 306-310. https://doi.org/10.1038/nchembio.2558

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Couturier, M, Ladevèze, S, Sulzenbacher, G, Ciano, L, Fanuel, M, Moreau, C, Villares, A, Cathala, B, Chaspoul, F, Herpoël-Gimbert, I, Grisel, S, Haon, M, Lenfant, N, Rogniaux, H, Ropartz, D, Davies, G, Rosso, M-N, Walton, PH, Henrissat, B, Berrin, J-G, Labourel, A & Frandsen, KE 2018, 'Lytic xylan oxidases from wood-decay fungi unlock biomass degradation', NATURE CHEMICAL BIOLOGY, vol. 14, no. 3, pp. 306-310. https://doi.org/10.1038/nchembio.2558

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Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Abstract

Bibliographical note

Access to Document

Other files and links

Gideon John Davies, FRS, FMedSci

Paul Howard Walton

Dissecting and exploiting lytic polysaccharide monooxygenases

Learning from marine wood borers; enzymes and mechanisms of lignocellulose digestion

Characterisation of new LPMO AA14 family

Cite this

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Abstract

Bibliographical note

Access to Document

Other files and links

Profiles

Gideon John Davies, FRS, FMedSci

Paul Howard Walton

Projects

Dissecting and exploiting lytic polysaccharide monooxygenases

Learning from marine wood borers; enzymes and mechanisms of lignocellulose digestion

Datasets

Characterisation of new LPMO AA14 family

Cite this