Macrocyclic polyenynes: A stereoselective route to vinyl-ether-containing skipped diene systems

Thomas O. Ronson, Martin H H Voelkel, Richard J K Taylor*, Ian J S Fairlamb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The stereoselective synthesis of a challenging macrocyclic polyene scaffold, containing a sensitive vinyl ether motif, has been accomplished using O,C-dilithiation/selective C-alkylation, Pd-catalysed etherification and Wittig reactions as key steps. An end-game macrocyclisation strategy employed a regio- and stereoselective Stille cross-coupling using Pd(Br)(N-Succ)(AsPh3)2 (AsCat) as the precatalyst.

Original languageEnglish
Pages (from-to)8034-8036
Number of pages3
JournalChemical Communications
Issue number38
Early online date20 Apr 2015
Publication statusPublished - 11 May 2015

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