Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling

Daniel Moyo, Lynette Beattie, Paul Simon Andrews, John Warren James Moore, Jonathan Ian Timmis, Amy Kathleen Sawtell, Stefan Hoehme, Adam T. Sampson, Paul Kaye

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Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with inflammation is limited. This may be particularly so in the case of granulomatous inflammation, where an excessive number and / or excessively florid granulomas can have significant pathological consequences. Here, we have combined transcriptomics, agent-based modeling and in vivo experimental approaches to study constraints on hepatic granuloma formation in a murine model of experimental leishmaniasis. We demonstrate that chemokine production by non-infected Kupffer cells in the Leishmania donovani-infected liver promotes competition with infected KCs for available iNKT cells, ultimately inhibiting the extent of granulomatous
30 inflammation. We propose trans-activation for chemokine production as a novel
31 broadly applicable mechanism that may operate early in infection to limit excessive
32 focal inflammation.
Original languageEnglish
Article number637
Number of pages10
JournalFrontiers in immunology
Issue number637
Publication statusPublished - 27 Mar 2018

Bibliographical note

© 2018 Moyo, Beattie, Andrews, Moore, Timmis, Sawtell, Hoehme, Sampson and Kay.

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