Abstract
Magnetic hyperthermia is being extensively researched as a viable cancer treatment option. It entails inserting magnetic nanoparticles (MNPs) into the tumor, followed by the application of an oscillating magnetic field, which produces localized heat capable of causing tumor cell death without affecting surrounding tissue. This chapter will provide an overview of the current state of magnetic hyperthermia, including the method’s physical foundation and its relationship to cell death mechanisms, which is an important factor in the development and optimization of hyperthermia therapy and its use in conjunction with other therapies. We also consider the thermodynamic mechanisms of heating and their relationship, via the bioheat equation, to the complex problem of understanding heating processes in the tumor environment, which is difficult due to the nature of the environment and the effects of particle aggregation. Finally, we discuss some emerging aspects of magnetic hyperthermia in areas such as drug release, magnetogenetics, and controlled warming after cryogenic preservation of organs for transplant. The potential for using MNPs for both therapy and diagnostic/detection is highlighted.
| Original language | English |
|---|---|
| Title of host publication | Magnetic Sensors and Actuators in Medicine |
| Subtitle of host publication | Materials, Devices, and Applications |
| Publisher | Elsevier |
| Chapter | 8 |
| Pages | 185-226 |
| Number of pages | 42 |
| ISBN (Electronic) | 9780128232941 |
| ISBN (Print) | 9780128236000 |
| DOIs | |
| Publication status | Published - 1 Jan 2023 |
Bibliographical note
Publisher Copyright:© 2023 Elsevier Ltd. All rights reserved.
Keywords
- biophysics
- condensed matter physics
- magnetic hyperthermia
- magnetic nanoparticles
- Tumor