Magnetic Interaction of Multifunctional Core–Shell Nanoparticles for Highly Effective Theranostics

TY - JOUR

T1 - Magnetic Interaction of Multifunctional Core–Shell Nanoparticles for Highly Effective Theranostics

AU - Yang, Ming Da

AU - Ho, Chien Hsin

AU - Ruta, Sergiu

AU - Chantrell, Roy

AU - Krycka, Kathryn

AU - Hovorka, Ondrej

AU - Chen, Fu Rong

AU - Lai, Ping Shan

AU - Lai, Chih Huang

N1 - © 2018 The Authors.

PY - 2018/12/13

Y1 - 2018/12/13

N2 - The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

AB - The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

KW - core–shell

KW - hyperthermia

KW - magnetic interaction

KW - magnetic resonance image

KW - theranostics

UR - http://www.scopus.com/inward/record.url?scp=85054724580&partnerID=8YFLogxK

U2 - 10.1002/adma.201802444

DO - 10.1002/adma.201802444

M3 - Article

AN - SCOPUS:85054724580

SN - 0935-9648

VL - 30

JO - Advanced Materials

JF - Advanced Materials

IS - 50

M1 - 1802444

ER -