Magnetic Interaction of Multifunctional Core–Shell Nanoparticles for Highly Effective Theranostics

Ming Da Yang, Chien Hsin Ho, Sergiu Ruta, Roy Chantrell, Kathryn Krycka, Ondrej Hovorka, Fu Rong Chen, Ping Shan Lai, Chih Huang Lai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

Original languageEnglish
Article number1802444
Number of pages9
JournalAdvanced Materials
Issue number50
Early online date11 Oct 2018
Publication statusPublished - 13 Dec 2018

Bibliographical note

© 2018 The Authors.


  • core–shell
  • hyperthermia
  • magnetic interaction
  • magnetic resonance image
  • theranostics

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