The York Research Database

Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects

Jones, N., Catta Preta, C., Lima, A. P. C. A. & Mottram, J. C., 13 Apr 2018

Article in ACS Infectious Diseases

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

Rutaganira, F. U., Barks, J., Dhason, M. S., Wang, Q., Lopez, M. S., Long, S., Radke, J. B., Jones, N. G., Maddirala, A. R., Janetka, J. W., El Bakkouri, M., Hui, R., Shokat, K. M. & Sibley, L. D., 28 Dec 2017

Article in JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasite

Duncan, S. M., Jones, N. G. & Mottram, J. C., Sep 2017

Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M., Jones, N. G., Ritchie, R., McCulloch, R. & Mottram, J. C., 21 Jul 2017

Article in Scientific Reports

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

Jones, N. G., Thomas, E. B., Brown, E., Dickens, N. J., Hammarton, T. C. & Mottram, J. C., 16 Jan 2014

Article in PLOS PATHOGENS

High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective Leishmania parasites

Findlay, R. C., Osman, M., Spence, K. A., Kaye, P. M., Walrad, P. B. & Wilson, L. G., 28 Jun 2021

Article in eLife

TMEM95 is a sperm membrane protein essential for mammalian fertilization.

Lamas-Toranzo, I., Hamze, J. G., Bianchi, E., Fernández-Fuertes, B., Pérez-Cerezales, S., Laguna-Barraza, R., Fernández-González, R., Lonergan, P., Gutiérrez-Adán, A., Wright, G. J., Jiménez-Movilla, M. & Bermejo-Álvarez, P., 2 Jun 2020

Article in eLife

Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

Bayfield, O. W., Steven, A. C. & Antson, A. A., 14 Apr 2020, (E-pub ahead of print)

Article in eLife

A neural mechanism for contextualizing fragmented inputs during naturalistic vision

Kaiser, D., Turini, J. & Cichy, R. M., 9 Oct 2019, (E-pub ahead of print)

Article in eLife

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B.

Vögtle, T., Sharma, S., Mori, J., Nagy, Z., Semeniak, D., Scandola, C., Geer, M. J., Smith, C. W., Lane, J., Pollack, S., Lassila, R., Jouppila, A., Barr, A. J., Ogg, D. J., Howard, T. D., McMiken, H. J., Warwicker, J., Geh, C., Rowlinson, R., Abbott, W. M. & 8 others, Eckly, A., Schulze, H., Wright, G. J., Mazharian, A., Fütterer, K., Rajesh, S., Douglas, M. R. & Senis, Y. A., 22 Aug 2019

Article in eLife