By the same authors

From the same journal

Mapping out the key carbon–carbon bond-forming steps in Mn-catalysed C–H functionalization

Research output: Contribution to journalArticle

Full text download(s)

Published copy (DOI)



Publication details

JournalNature Catalysis
DateAccepted/In press - 16 Aug 2018
DateE-pub ahead of print - 8 Oct 2018
DatePublished (current) - 1 Nov 2018
Number of pages11
Pages (from-to)830-840
Early online date8/10/18
Original languageEnglish


Detailed understanding of the mechanistic processes that underpin transition metal-catalysed reactions allows for the rational and de novo development of complexes with enhanced activity, efficacy and wider substrate scope. Directly observing bond cleaving and forming events underpinning a catalytic reaction is non-trivial as the species that facilitate these steps are frequently short-lived and present at low concentrations. Here we describe how the photochemical activation of a manganese precatalyst, [Mn(ppy)(CO)4], results in selective loss of a carbonyl ligand simulating entry into the catalytic cycle for Mn-promoted C–H bond functionalisation. Time-resolved infra-red spectroscopy (ps-ms timescale) allows direct observation of the species responsible for the essential carbon-carbon bond formation step and an evaluation of the factors affecting its rate. The mechanistic information prompted discovery of a new photochemically initiated manganese-promoted coupling of phenylacetylene with 2-phenylpyrindine. This study provides unique insight into the mechanistic pathways which underpin catalysis by an Earth-abundant metal, manganese.

Bibliographical note

© 2018 Springer Nature Limited. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations