Mapping the Human Cell Surface Interactome: A Key to Decode Cell-to-Cell Communication

TY - JOUR

T1 - Mapping the Human Cell Surface Interactome

T2 - A Key to Decode Cell-to-Cell Communication

AU - Shilts, Jarrod

AU - Wright, Gavin J

PY - 2024/8

Y1 - 2024/8

N2 - Proteins on the surfaces of cells serve as physical connection points to bridge one cell with another, enabling direct communication between cells and cohesive structure. As biomedical research makes the leap from characterizing individual cells toward understanding the multicellular organization of the human body, the binding interactions between molecules on the surfaces of cells are foundational both for computational models and for clinical efforts to exploit these influential receptor pathways. To achieve this grander vision, we must assemble the full interactome of ways surface proteins can link together. This review investigates how close we are to knowing the human cell surface protein interactome. We summarize the current state of databases and systematic technologies to assemble surface protein interactomes, while highlighting substantial gaps that remain. We aim for this to serve as a road map for eventually building a more robust picture of the human cell surface protein interactome.

AB - Proteins on the surfaces of cells serve as physical connection points to bridge one cell with another, enabling direct communication between cells and cohesive structure. As biomedical research makes the leap from characterizing individual cells toward understanding the multicellular organization of the human body, the binding interactions between molecules on the surfaces of cells are foundational both for computational models and for clinical efforts to exploit these influential receptor pathways. To achieve this grander vision, we must assemble the full interactome of ways surface proteins can link together. This review investigates how close we are to knowing the human cell surface protein interactome. We summarize the current state of databases and systematic technologies to assemble surface protein interactomes, while highlighting substantial gaps that remain. We aim for this to serve as a road map for eventually building a more robust picture of the human cell surface protein interactome.

KW - Humans

KW - Cell Communication/physiology

KW - Membrane Proteins/metabolism

KW - Protein Interaction Mapping/methods

KW - Cell Membrane/metabolism

U2 - 10.1146/annurev-biodatasci-102523-103821

DO - 10.1146/annurev-biodatasci-102523-103821

M3 - Review article

C2 - 38723658

SN - 2574-3414

VL - 7

SP - 155

EP - 177

JO - Annual review of biomedical data science

JF - Annual review of biomedical data science

ER -