Abstract
Abstract
Purpose In order to enable cost-utility analysis of shoulder pain conditions and treatments, this study aimed to develop
and evaluate mapping algorithms to estimate the EQ-5D health index from the Oxford Shoulder Score (OSS) when health
outcomes are only assessed with the OSS.
Methods 5437 paired OSS and EQ-5D questionnaire responses from four national multicentre randomised controlled trials
investigating diferent shoulder pathologies and treatments were split into training and testing samples. Separate EQ-5D-3L
and EQ-5D-5L analyses were undertaken. Transfer to utility (TTU) regression (univariate linear, polynomial, spline, multivariable linear, two-part logistic-linear, tobit and adjusted limited dependent variable mixture models) and response mapping (ordered logistic regression and seemingly unrelated regression (SUR)) models were developed on the training sample.
These were internally validated, and their performance evaluated on the testing sample. Model performance was evaluated
over 100-fold repeated training–testing sample splits.
Results For the EQ-5D-3L analysis, the multivariable linear and splines models had the lowest mean square error (MSE) of
0.0415. The SUR model had the lowest mean absolute error (MAE) of 0.136. Model performance was greatest in the midrange and best health states, and lowest in poor health states.
For the EQ-5D-5L analyses, the multivariable linear and splines models had the lowest MSE (0.0241–0.0278) while the
SUR models had the lowest MAE (0.105–0.113).
Conclusion The developed models now allow accurate estimation of the EQ-5D health index when only the OSS responses
are available as a measure of patient-reported health outcome.
Purpose In order to enable cost-utility analysis of shoulder pain conditions and treatments, this study aimed to develop
and evaluate mapping algorithms to estimate the EQ-5D health index from the Oxford Shoulder Score (OSS) when health
outcomes are only assessed with the OSS.
Methods 5437 paired OSS and EQ-5D questionnaire responses from four national multicentre randomised controlled trials
investigating diferent shoulder pathologies and treatments were split into training and testing samples. Separate EQ-5D-3L
and EQ-5D-5L analyses were undertaken. Transfer to utility (TTU) regression (univariate linear, polynomial, spline, multivariable linear, two-part logistic-linear, tobit and adjusted limited dependent variable mixture models) and response mapping (ordered logistic regression and seemingly unrelated regression (SUR)) models were developed on the training sample.
These were internally validated, and their performance evaluated on the testing sample. Model performance was evaluated
over 100-fold repeated training–testing sample splits.
Results For the EQ-5D-3L analysis, the multivariable linear and splines models had the lowest mean square error (MSE) of
0.0415. The SUR model had the lowest mean absolute error (MAE) of 0.136. Model performance was greatest in the midrange and best health states, and lowest in poor health states.
For the EQ-5D-5L analyses, the multivariable linear and splines models had the lowest MSE (0.0241–0.0278) while the
SUR models had the lowest MAE (0.105–0.113).
Conclusion The developed models now allow accurate estimation of the EQ-5D health index when only the OSS responses
are available as a measure of patient-reported health outcome.
| Original language | English |
|---|---|
| Number of pages | 12 |
| Journal | Quality of life research |
| Early online date | 28 Sept 2022 |
| DOIs | |
| Publication status | E-pub ahead of print - 28 Sept 2022 |