Master equation approach to the assembly of viral capsids

TY - JOUR

T1 - Master equation approach to the assembly of viral capsids

AU - Keef, T.

AU - Micheletti, C.

AU - Twarock, R.

PY - 2006/10/7

Y1 - 2006/10/7

N2 - The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for anti-viral drug design. (c) 2006 Elsevier Ltd. All rights reserved.

AB - The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for anti-viral drug design. (c) 2006 Elsevier Ltd. All rights reserved.

KW - viral capsid assembly

KW - master equation

KW - SV40 virus

KW - VIRUS CAPSIDS

KW - PROTEIN COMPLEXES

KW - MODEL

KW - GROWTH

KW - NUCLEATION

KW - FULLERENES

KW - RESOLUTION

KW - SYMMETRY

KW - DYNAMICS

KW - KINETICS

U2 - 10.1016/j.jtbi.2006.04.023

DO - 10.1016/j.jtbi.2006.04.023

M3 - Article

SN - 0022-5193

VL - 242

SP - 713

EP - 721

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 3

ER -