Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Casper de Boer; Zachary Armstrong; Vincent A. J. Lit; Uri Barash; Gijs Ruijgrok; Ilanit Boyango; Merle M. Weitzenberg; Sybrin P. Schröder; Alexi J. C. Sarris; Nico J. Meeuwenoord; Pedro Bule; Yasmine Kayal; Neta Ilan; Jeroen D. C. Codée; Israel Vlodavsky; Herman S. Overkleeft; Gideon J. Davies; Liang Wu

doi:10.1073/pnas.2203167119

Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Casper de Boer
, Zachary Armstrong
, Vincent A. J. Lit
, Uri Barash
, Gijs Ruijgrok
, Ilanit Boyango
, Merle M. Weitzenberg
, Sybrin P. Schröder
, Alexi J. C. Sarris
, Nico J. Meeuwenoord
, Pedro Bule
, Yasmine Kayal
, Neta Ilan
, Jeroen D. C. Codée
, Israel Vlodavsky
, Herman S. Overkleeft
, Gideon J. Davies
, Liang Wu

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e2203167119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	31
DOIs	https://doi.org/10.1073/pnas.2203167119
Publication status	Published - 26 Jul 2022

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10.1073/pnas.2203167119Licence: CC BY

pnas.2203167119
© 2022 the Author(s)
Final published version, 2.31 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. (Principal investigator)
EUROPEAN COMMISSION
1/06/21 → 31/05/28
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 5/07/28
Project: Research project (funded) › Research
Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis
Davies, G. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/01/18 → 31/12/21
Project: Research project (funded) › Research

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Boer, C. D., Armstrong, Z., Lit, V. A. J., Barash, U., Ruijgrok, G., Boyango, I., Weitzenberg, M. M., Schröder, S. P., Sarris, A. J. C., Meeuwenoord, N. J., Bule, P., Kayal, Y., Ilan, N., Codée, J. D. C., Vlodavsky, I., Overkleeft, H. S., Davies, G. J., & Wu, L. (2022). Mechanism based heparanase inhibitors reduce cancer metastasis in vivo. Proceedings of the National Academy of Sciences of the United States of America, 119(31), Article e2203167119. https://doi.org/10.1073/pnas.2203167119

@article{f3f53ded0eb04c50b7e18ffdd9f04505,

title = "Mechanism based heparanase inhibitors reduce cancer metastasis in vivo",

author = "Boer, \{Casper de\} and Zachary Armstrong and Lit, \{Vincent A. J.\} and Uri Barash and Gijs Ruijgrok and Ilanit Boyango and Weitzenberg, \{Merle M.\} and Schr{\"o}der, \{Sybrin P.\} and Sarris, \{Alexi J. C.\} and Meeuwenoord, \{Nico J.\} and Pedro Bule and Yasmine Kayal and Neta Ilan and Cod{\'e}e, \{Jeroen D. C.\} and Israel Vlodavsky and Overkleeft, \{Herman S.\} and Davies, \{Gideon J.\} and Liang Wu",

note = "{\textcopyright} 2022 the Author(s)",

year = "2022",

month = jul,

day = "26",

doi = "10.1073/pnas.2203167119",

language = "English",

volume = "119",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Boer, CD, Armstrong, Z, Lit, VAJ, Barash, U, Ruijgrok, G, Boyango, I, Weitzenberg, MM, Schröder, SP, Sarris, AJC, Meeuwenoord, NJ, Bule, P, Kayal, Y, Ilan, N, Codée, JDC, Vlodavsky, I, Overkleeft, HS, Davies, GJ & Wu, L 2022, 'Mechanism based heparanase inhibitors reduce cancer metastasis in vivo', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 31, e2203167119. https://doi.org/10.1073/pnas.2203167119

TY - JOUR

T1 - Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

AU - Boer, Casper de

AU - Armstrong, Zachary

AU - Lit, Vincent A. J.

AU - Barash, Uri

AU - Ruijgrok, Gijs

AU - Boyango, Ilanit

AU - Weitzenberg, Merle M.

AU - Schröder, Sybrin P.

AU - Sarris, Alexi J. C.

AU - Meeuwenoord, Nico J.

AU - Bule, Pedro

AU - Kayal, Yasmine

AU - Ilan, Neta

AU - Codée, Jeroen D. C.

AU - Vlodavsky, Israel

AU - Overkleeft, Herman S.

AU - Davies, Gideon J.

AU - Wu, Liang

PY - 2022/7/26

Y1 - 2022/7/26

U2 - 10.1073/pnas.2203167119

DO - 10.1073/pnas.2203167119

M3 - Article

SN - 0027-8424

VL - 119

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 31

M1 - e2203167119

ER -

Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Bibliographical note

Access to Document

Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis

Cite this