Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Casper de Boer; Zachary Armstrong; Vincent A. J. Lit; Uri Barash; Gijs Ruijgrok; Ilanit Boyango; Merle M. Weitzenberg; Sybrin P. Schröder; Alexi J. C. Sarris; Nico J. Meeuwenoord; Pedro Bule; Yasmine Kayal; Neta Ilan; Jeroen D. C. Codée; Israel Vlodavsky; Herman S. Overkleeft; Gideon J. Davies; Liang Wu

doi:10.1073/pnas.2203167119

Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Casper de Boer, Zachary Armstrong, Vincent A. J. Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M. Weitzenberg, Sybrin P. Schröder, Alexi J. C. Sarris, Nico J. Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D. C. Codée, Israel Vlodavsky, Herman S. Overkleeft, Gideon J. Davies, Liang Wu

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e2203167119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	31
DOIs	https://doi.org/10.1073/pnas.2203167119
Publication status	Published - 26 Jul 2022

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10.1073/pnas.2203167119Licence: CC BY

pnas.2203167119
© 2022 the Author(s)
Final published version, 2.31 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
DAVIES, G. J. (Principal investigator)
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
DAVIES, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/26
Project: Research project (funded) › Research
Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis
DAVIES, G. J. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/01/18 → 31/12/21
Project: Research project (funded) › Research

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Boer, C. D., Armstrong, Z., Lit, V. A. J., Barash, U., Ruijgrok, G., Boyango, I., Weitzenberg, M. M., Schröder, S. P., Sarris, A. J. C., Meeuwenoord, N. J., Bule, P., Kayal, Y., Ilan, N., Codée, J. D. C., Vlodavsky, I., Overkleeft, H. S., Davies, G. J., & Wu, L. (2022). Mechanism based heparanase inhibitors reduce cancer metastasis in vivo. Proceedings of the National Academy of Sciences of the United States of America, 119(31), Article e2203167119. https://doi.org/10.1073/pnas.2203167119

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title = "Mechanism based heparanase inhibitors reduce cancer metastasis in vivo",

author = "Boer, {Casper de} and Zachary Armstrong and Lit, {Vincent A. J.} and Uri Barash and Gijs Ruijgrok and Ilanit Boyango and Weitzenberg, {Merle M.} and Schr{\"o}der, {Sybrin P.} and Sarris, {Alexi J. C.} and Meeuwenoord, {Nico J.} and Pedro Bule and Yasmine Kayal and Neta Ilan and Cod{\'e}e, {Jeroen D. C.} and Israel Vlodavsky and Overkleeft, {Herman S.} and Davies, {Gideon J.} and Liang Wu",

note = "{\textcopyright} 2022 the Author(s)",

year = "2022",

month = jul,

day = "26",

doi = "10.1073/pnas.2203167119",

language = "English",

volume = "119",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Boer, CD, Armstrong, Z, Lit, VAJ, Barash, U, Ruijgrok, G, Boyango, I, Weitzenberg, MM, Schröder, SP, Sarris, AJC, Meeuwenoord, NJ, Bule, P, Kayal, Y, Ilan, N, Codée, JDC, Vlodavsky, I, Overkleeft, HS, Davies, GJ & Wu, L 2022, 'Mechanism based heparanase inhibitors reduce cancer metastasis in vivo', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 31, e2203167119. https://doi.org/10.1073/pnas.2203167119

TY - JOUR

T1 - Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

AU - Boer, Casper de

AU - Armstrong, Zachary

AU - Lit, Vincent A. J.

AU - Barash, Uri

AU - Ruijgrok, Gijs

AU - Boyango, Ilanit

AU - Weitzenberg, Merle M.

AU - Schröder, Sybrin P.

AU - Sarris, Alexi J. C.

AU - Meeuwenoord, Nico J.

AU - Bule, Pedro

AU - Kayal, Yasmine

AU - Ilan, Neta

AU - Codée, Jeroen D. C.

AU - Vlodavsky, Israel

AU - Overkleeft, Herman S.

AU - Davies, Gideon J.

AU - Wu, Liang

PY - 2022/7/26

Y1 - 2022/7/26

U2 - 10.1073/pnas.2203167119

DO - 10.1073/pnas.2203167119

M3 - Article

SN - 0027-8424

VL - 119

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 31

M1 - e2203167119

ER -

Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

Bibliographical note

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Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis

Cite this