Mechanisms of hyperthermia in magnetic nanoparticles

Gonzalo Vallejo Fernandez; O Whear; A G Roca; S Hussain; J Timmis; V Patel; Kevin Dermot O'Grady

doi:10.1088/0022-3727/46/31/312001

Mechanisms of hyperthermia in magnetic nanoparticles

Gonzalo Vallejo Fernandez, O Whear, A G Roca, S Hussain, J Timmis, V Patel, Kevin Dermot O'Grady

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

We report on a theoretical framework for magnetic hyperthermia where the amount of heat generated by nanoparticles can be understood when both the physical and hydrodynamic size distributions are known accurately. The model is validated by studying the magnetic, colloidal and heating properties of magnetite/maghemite nanoparticles of different sizes dispersed in solvents of varying viscosity. We show that heating arising due to susceptibility losses can be neglected with hysteresis loss being the dominant mechanism. We show that it is crucial to measure the specific absorption rate of samples only when embedded in a solid matrix to avoid heating by stirring. However the data shows that distributions of both size and anisotropy must be included in theoretical models.

Original language	English
Article number	312001
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Physics D: Applied Physics
Volume	46
Issue number	31
Early online date	10 Jul 2013
DOIs	https://doi.org/10.1088/0022-3727/46/31/312001
Publication status	Published - 7 Aug 2013

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10.1088/0022-3727/46/31/312001

http://stacks.iop.org/JPhysD/46/312001

Cite this

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title = "Mechanisms of hyperthermia in magnetic nanoparticles",

abstract = "We report on a theoretical framework for magnetic hyperthermia where the amount of heat generated by nanoparticles can be understood when both the physical and hydrodynamic size distributions are known accurately. The model is validated by studying the magnetic, colloidal and heating properties of magnetite/maghemite nanoparticles of different sizes dispersed in solvents of varying viscosity. We show that heating arising due to susceptibility losses can be neglected with hysteresis loss being the dominant mechanism. We show that it is crucial to measure the specific absorption rate of samples only when embedded in a solid matrix to avoid heating by stirring. However the data shows that distributions of both size and anisotropy must be included in theoretical models.",

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AU - Whear, O

AU - G Roca, A

AU - Hussain, S

AU - Timmis, J

AU - Patel, V

AU - O'Grady, Kevin Dermot

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AB - We report on a theoretical framework for magnetic hyperthermia where the amount of heat generated by nanoparticles can be understood when both the physical and hydrodynamic size distributions are known accurately. The model is validated by studying the magnetic, colloidal and heating properties of magnetite/maghemite nanoparticles of different sizes dispersed in solvents of varying viscosity. We show that heating arising due to susceptibility losses can be neglected with hysteresis loss being the dominant mechanism. We show that it is crucial to measure the specific absorption rate of samples only when embedded in a solid matrix to avoid heating by stirring. However the data shows that distributions of both size and anisotropy must be included in theoretical models.

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