Mechanisms of therapy-related carcinogenesis

Research output: Contribution to journalLiterature review

Published copy (DOI)

Author(s)

  • J M Allan
  • B T Lois

Department/unit(s)

Publication details

JournalNature reviews cancer
DatePublished - Dec 2005
Issue number12
Volume5
Number of pages13
Pages (from-to)943-955
Original languageEnglish

Abstract

Therapy-related cancers, defined as second primary cancers that arise as a consequence of chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology. Knowledge of the specific nature of the initiating exposure and exactly when it occurred has made it easier to identify crucial genetic events and to model these in vitro and in vivo. As such, the study of therapy-related cancers has led to the elucidation of discrete mechanisms of carcinogenesis, including DNA double-strand-break-induced gene translocation and genomic instability conferred by loss of DNA repair. Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers.

    Research areas

  • ACUTE MYELOID-LEUKEMIA, DNA MISMATCH REPAIR, BREAKPOINT CLUSTER REGION, TOPOISOMERASE-II CLEAVAGE, CELL-CYCLE ARREST, HODGKINS-DISEASE, IONIZING-RADIATION, MICROSATELLITE INSTABILITY, BREAST-CANCER, OVARIAN-CANCER

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