Mechanisms of therapy-related carcinogenesis

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Mechanisms of therapy-related carcinogenesis. / Allan, J M; Lois, B T.

In: Nature reviews cancer, Vol. 5, No. 12, 12.2005, p. 943-955.

Research output: Contribution to journalLiterature reviewpeer-review

Harvard

Allan, JM & Lois, BT 2005, 'Mechanisms of therapy-related carcinogenesis', Nature reviews cancer, vol. 5, no. 12, pp. 943-955. https://doi.org/10.1038/nrc1749

APA

Allan, J. M., & Lois, B. T. (2005). Mechanisms of therapy-related carcinogenesis. Nature reviews cancer, 5(12), 943-955. https://doi.org/10.1038/nrc1749

Vancouver

Allan JM, Lois BT. Mechanisms of therapy-related carcinogenesis. Nature reviews cancer. 2005 Dec;5(12):943-955. https://doi.org/10.1038/nrc1749

Author

Allan, J M ; Lois, B T. / Mechanisms of therapy-related carcinogenesis. In: Nature reviews cancer. 2005 ; Vol. 5, No. 12. pp. 943-955.

Bibtex - Download

@article{58a5dfbb53eb4f51b5a7902b3f70c6fa,
title = "Mechanisms of therapy-related carcinogenesis",
abstract = "Therapy-related cancers, defined as second primary cancers that arise as a consequence of chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology. Knowledge of the specific nature of the initiating exposure and exactly when it occurred has made it easier to identify crucial genetic events and to model these in vitro and in vivo. As such, the study of therapy-related cancers has led to the elucidation of discrete mechanisms of carcinogenesis, including DNA double-strand-break-induced gene translocation and genomic instability conferred by loss of DNA repair. Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers.",
keywords = "ACUTE MYELOID-LEUKEMIA, DNA MISMATCH REPAIR, BREAKPOINT CLUSTER REGION, TOPOISOMERASE-II CLEAVAGE, CELL-CYCLE ARREST, HODGKINS-DISEASE, IONIZING-RADIATION, MICROSATELLITE INSTABILITY, BREAST-CANCER, OVARIAN-CANCER",
author = "Allan, {J M} and Lois, {B T}",
year = "2005",
month = dec,
doi = "10.1038/nrc1749",
language = "English",
volume = "5",
pages = "943--955",
journal = "Nature reviews cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "12",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Mechanisms of therapy-related carcinogenesis

AU - Allan, J M

AU - Lois, B T

PY - 2005/12

Y1 - 2005/12

N2 - Therapy-related cancers, defined as second primary cancers that arise as a consequence of chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology. Knowledge of the specific nature of the initiating exposure and exactly when it occurred has made it easier to identify crucial genetic events and to model these in vitro and in vivo. As such, the study of therapy-related cancers has led to the elucidation of discrete mechanisms of carcinogenesis, including DNA double-strand-break-induced gene translocation and genomic instability conferred by loss of DNA repair. Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers.

AB - Therapy-related cancers, defined as second primary cancers that arise as a consequence of chemotherapy and/or radiotherapy, are unusual in that they have a well-defined aetiology. Knowledge of the specific nature of the initiating exposure and exactly when it occurred has made it easier to identify crucial genetic events and to model these in vitro and in vivo. As such, the study of therapy-related cancers has led to the elucidation of discrete mechanisms of carcinogenesis, including DNA double-strand-break-induced gene translocation and genomic instability conferred by loss of DNA repair. Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers.

KW - ACUTE MYELOID-LEUKEMIA

KW - DNA MISMATCH REPAIR

KW - BREAKPOINT CLUSTER REGION

KW - TOPOISOMERASE-II CLEAVAGE

KW - CELL-CYCLE ARREST

KW - HODGKINS-DISEASE

KW - IONIZING-RADIATION

KW - MICROSATELLITE INSTABILITY

KW - BREAST-CANCER

KW - OVARIAN-CANCER

U2 - 10.1038/nrc1749

DO - 10.1038/nrc1749

M3 - Literature review

VL - 5

SP - 943

EP - 955

JO - Nature reviews cancer

JF - Nature reviews cancer

SN - 1474-175X

IS - 12

ER -