Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

Harriet Chidwick; Martin Anthony Fascione

doi:10.1039/C9OB02433F

Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

Harriet Chidwick, Martin Anthony Fascione

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The non-mammalian nonulosonic acid sugar pseudaminic acid (Pse) is present on the surface of a number of human pathogens including Campylobacter jejuni and Helicobacter pylori and other bacteria such as multidrug resistant Acinetobacter baumannii. It is likely important for evasion of the host immune sysyem, and also plays a role in bacterial motility through flagellin glycosylation. Herein we review the mechanistic and structural characterisation of the enzymes responsible for the biosynthesis of the Pse parent structure, Pse5Ac7Ac in bacteria.

Original language	English
Pages (from-to)	799-809
Journal	Organic and Biomolecular Chemistry
Volume	18
Early online date	23 Dec 2019
DOIs	https://doi.org/10.1039/C9OB02433F
Publication status	E-pub ahead of print - 23 Dec 2019

Bibliographical note

© Royal Society of Chemistry 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Access to Document

10.1039/C9OB02433F

Pse review_09.12.19_full
© Royal Society of Chemistry 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Accepted author manuscript, 3.35 MBLicence: Unspecified

Cite this

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