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Mechanistic insights into glycosidase chemistry

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Publication details

JournalCurrent Opinion in Chemical Biology
DatePublished - Oct 2008
Issue number5
Volume12
Number of pages17
Pages (from-to)539-555
Original languageEnglish

Abstract

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.

    Research areas

  • TRANSITION-STATE ANALOGS, BETA-N-ACETYLGLUCOSAMINIDASES, ALPHA-MANNOSIDASE-II, COVALENT INTERMEDIATE, KINETIC-ANALYSIS, O-GLCNACASE, CATALYTIC MECHANISM, THERMOTOGA-MARITIMA, CRYSTAL-STRUCTURE, STRUCTURAL BASIS

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