Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Paige M Bracci; Yolanda Benavente; Jennifer J Turner; Ora Paltiel; Susan L Slager; Claire M Vajdic; Aaron D Norman; James R Cerhan; Brian C H Chiu; Nikolaus Becker; Pierluigi Cocco; Ahmet Dogan; Alexandra Nieters; Elizabeth A Holly; Eleanor V Kane; Karin E Smedby; Marc Maynadié; John J Spinelli; Eve Roman; Bengt Glimelius; Sophia S Wang; Joshua N Sampson; Lindsay M Morton; Silvia de Sanjosé

doi:10.1093/jncimonographs/lgu011

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Paige M Bracci, Yolanda Benavente, Jennifer J Turner, Ora Paltiel, Susan L Slager, Claire M Vajdic, Aaron D Norman, James R Cerhan, Brian C H Chiu, Nikolaus Becker, Pierluigi Cocco, Ahmet Dogan, Alexandra Nieters, Elizabeth A Holly, Eleanor V Kane, Karin E Smedby, Marc Maynadié, John J Spinelli, Eve Roman, Bengt GlimeliusSophia S Wang, Joshua N Sampson, Lindsay M Morton, Silvia de Sanjosé

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%-10% of non-Hodgkin lymphoma cases. A detailed evaluation of the independent effects of risk factors for MZL and its subtypes has not been conducted.

METHODS: Data were pooled from 1052 MZL cases (extranodal [EMZL] = 633, nodal [NMZL] = 157, splenic [SMZL] = 140) and 13766 controls from 12 case-control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS: Novel findings for MZL subtypes include increased risk for B-cell activating autoimmune conditions (EMZL OR = 6.40, 95% CI = 4.24 to 9.68; NMZL OR = 7.80, 95% CI = 3.32 to 18.33; SMZL OR = 4.25, 95% CI = 1.49 to 12.14), hepatitis C virus seropositivity (EMZL OR = 5.29, 95% CI = 2.48 to 11.28), self-reported peptic ulcers (EMZL OR = 1.83, 95% CI = 1.35 to 2.49), asthma without other atopy (SMZL OR = 2.28, 95% CI = 1.23 to 4.23), family history of hematologic cancer (EMZL OR = 1.90, 95% CI = 1.37 to 2.62) and of non-Hodgkin lymphoma (NMZL OR = 2.82, 95% CI = 1.33 to 5.98), permanent hairdye use (SMZL OR = 6.59, 95% CI = 1.54 to 28.17), and occupation as a metalworker (NMZL OR = 3.56, 95% CI = 1.67 to 7.58). Reduced risks were observed with consumption of any alcohol (EMZL fourth quartile OR = 0.48, 95% CI = 0.28 to 0.82) and lower consumption of wine (NMZL first to third quartile ORs < 0.45) compared with nondrinkers, and occupation as a teacher (EMZL OR = 0.58, 95% CI = 0.37 to 0.88).

CONCLUSION: Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found.

Original language	English
Pages (from-to)	52-65
Number of pages	14
Journal	Journal of the National Cancer Institute. Monographs
Volume	2014
Issue number	48
DOIs	https://doi.org/10.1093/jncimonographs/lgu011
Publication status	Published - 2014

Bibliographical note

Published by Oxford University Press 2014.

Access to Document

10.1093/jncimonographs/lgu011

Cite this

Bracci, P. M., Benavente, Y., Turner, J. J., Paltiel, O., Slager, S. L., Vajdic, C. M., Norman, A. D., Cerhan, J. R., Chiu, B. C. H., Becker, N., Cocco, P., Dogan, A., Nieters, A., Holly, E. A., Kane, E. V., Smedby, K. E., Maynadié, M., Spinelli, J. J., Roman, E., ... de Sanjosé, S. (2014). Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project. Journal of the National Cancer Institute. Monographs, 2014(48), 52-65. https://doi.org/10.1093/jncimonographs/lgu011

@article{daa005fd4fa4436187e77a977141f03a,

title = "Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project",

abstract = "BACKGROUND: Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%-10% of non-Hodgkin lymphoma cases. A detailed evaluation of the independent effects of risk factors for MZL and its subtypes has not been conducted.METHODS: Data were pooled from 1052 MZL cases (extranodal [EMZL] = 633, nodal [NMZL] = 157, splenic [SMZL] = 140) and 13766 controls from 12 case-control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: Novel findings for MZL subtypes include increased risk for B-cell activating autoimmune conditions (EMZL OR = 6.40, 95% CI = 4.24 to 9.68; NMZL OR = 7.80, 95% CI = 3.32 to 18.33; SMZL OR = 4.25, 95% CI = 1.49 to 12.14), hepatitis C virus seropositivity (EMZL OR = 5.29, 95% CI = 2.48 to 11.28), self-reported peptic ulcers (EMZL OR = 1.83, 95% CI = 1.35 to 2.49), asthma without other atopy (SMZL OR = 2.28, 95% CI = 1.23 to 4.23), family history of hematologic cancer (EMZL OR = 1.90, 95% CI = 1.37 to 2.62) and of non-Hodgkin lymphoma (NMZL OR = 2.82, 95% CI = 1.33 to 5.98), permanent hairdye use (SMZL OR = 6.59, 95% CI = 1.54 to 28.17), and occupation as a metalworker (NMZL OR = 3.56, 95% CI = 1.67 to 7.58). Reduced risks were observed with consumption of any alcohol (EMZL fourth quartile OR = 0.48, 95% CI = 0.28 to 0.82) and lower consumption of wine (NMZL first to third quartile ORs < 0.45) compared with nondrinkers, and occupation as a teacher (EMZL OR = 0.58, 95% CI = 0.37 to 0.88).CONCLUSION: Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found.",

author = "Bracci, {Paige M} and Yolanda Benavente and Turner, {Jennifer J} and Ora Paltiel and Slager, {Susan L} and Vajdic, {Claire M} and Norman, {Aaron D} and Cerhan, {James R} and Chiu, {Brian C H} and Nikolaus Becker and Pierluigi Cocco and Ahmet Dogan and Alexandra Nieters and Holly, {Elizabeth A} and Kane, {Eleanor V} and Smedby, {Karin E} and Marc Maynadi{\'e} and Spinelli, {John J} and Eve Roman and Bengt Glimelius and Wang, {Sophia S} and Sampson, {Joshua N} and Morton, {Lindsay M} and {de Sanjos{\'e}}, Silvia",

note = "Published by Oxford University Press 2014.",

year = "2014",

doi = "10.1093/jncimonographs/lgu011",

language = "English",

volume = "2014",

pages = "52--65",

journal = "Journal of the National Cancer Institute. Monographs",

issn = "1052-6773",

publisher = "Oxford University Press",

number = "48",

}

Bracci, PM, Benavente, Y, Turner, JJ, Paltiel, O, Slager, SL, Vajdic, CM, Norman, AD, Cerhan, JR, Chiu, BCH, Becker, N, Cocco, P, Dogan, A, Nieters, A, Holly, EA, Kane, EV, Smedby, KE, Maynadié, M, Spinelli, JJ, Roman, E, Glimelius, B, Wang, SS, Sampson, JN, Morton, LM & de Sanjosé, S 2014, 'Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project', Journal of the National Cancer Institute. Monographs, vol. 2014, no. 48, pp. 52-65. https://doi.org/10.1093/jncimonographs/lgu011

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project. / Bracci, Paige M; Benavente, Yolanda; Turner, Jennifer J et al.
In: Journal of the National Cancer Institute. Monographs, Vol. 2014, No. 48, 2014, p. 52-65.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma

T2 - The InterLymph Non-Hodgkin Lymphoma Subtypes Project

AU - Bracci, Paige M

AU - Benavente, Yolanda

AU - Turner, Jennifer J

AU - Paltiel, Ora

AU - Slager, Susan L

AU - Vajdic, Claire M

AU - Norman, Aaron D

AU - Cerhan, James R

AU - Chiu, Brian C H

AU - Becker, Nikolaus

AU - Cocco, Pierluigi

AU - Dogan, Ahmet

AU - Nieters, Alexandra

AU - Holly, Elizabeth A

AU - Kane, Eleanor V

AU - Smedby, Karin E

AU - Maynadié, Marc

AU - Spinelli, John J

AU - Roman, Eve

AU - Glimelius, Bengt

AU - Wang, Sophia S

AU - Sampson, Joshua N

AU - Morton, Lindsay M

AU - de Sanjosé, Silvia

N1 - Published by Oxford University Press 2014.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%-10% of non-Hodgkin lymphoma cases. A detailed evaluation of the independent effects of risk factors for MZL and its subtypes has not been conducted.METHODS: Data were pooled from 1052 MZL cases (extranodal [EMZL] = 633, nodal [NMZL] = 157, splenic [SMZL] = 140) and 13766 controls from 12 case-control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: Novel findings for MZL subtypes include increased risk for B-cell activating autoimmune conditions (EMZL OR = 6.40, 95% CI = 4.24 to 9.68; NMZL OR = 7.80, 95% CI = 3.32 to 18.33; SMZL OR = 4.25, 95% CI = 1.49 to 12.14), hepatitis C virus seropositivity (EMZL OR = 5.29, 95% CI = 2.48 to 11.28), self-reported peptic ulcers (EMZL OR = 1.83, 95% CI = 1.35 to 2.49), asthma without other atopy (SMZL OR = 2.28, 95% CI = 1.23 to 4.23), family history of hematologic cancer (EMZL OR = 1.90, 95% CI = 1.37 to 2.62) and of non-Hodgkin lymphoma (NMZL OR = 2.82, 95% CI = 1.33 to 5.98), permanent hairdye use (SMZL OR = 6.59, 95% CI = 1.54 to 28.17), and occupation as a metalworker (NMZL OR = 3.56, 95% CI = 1.67 to 7.58). Reduced risks were observed with consumption of any alcohol (EMZL fourth quartile OR = 0.48, 95% CI = 0.28 to 0.82) and lower consumption of wine (NMZL first to third quartile ORs < 0.45) compared with nondrinkers, and occupation as a teacher (EMZL OR = 0.58, 95% CI = 0.37 to 0.88).CONCLUSION: Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found.

AB - BACKGROUND: Marginal zone lymphoma (MZL), comprised of nodal, extranodal, and splenic subtypes, accounts for 5%-10% of non-Hodgkin lymphoma cases. A detailed evaluation of the independent effects of risk factors for MZL and its subtypes has not been conducted.METHODS: Data were pooled from 1052 MZL cases (extranodal [EMZL] = 633, nodal [NMZL] = 157, splenic [SMZL] = 140) and 13766 controls from 12 case-control studies. Adjusted unconditional logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: Novel findings for MZL subtypes include increased risk for B-cell activating autoimmune conditions (EMZL OR = 6.40, 95% CI = 4.24 to 9.68; NMZL OR = 7.80, 95% CI = 3.32 to 18.33; SMZL OR = 4.25, 95% CI = 1.49 to 12.14), hepatitis C virus seropositivity (EMZL OR = 5.29, 95% CI = 2.48 to 11.28), self-reported peptic ulcers (EMZL OR = 1.83, 95% CI = 1.35 to 2.49), asthma without other atopy (SMZL OR = 2.28, 95% CI = 1.23 to 4.23), family history of hematologic cancer (EMZL OR = 1.90, 95% CI = 1.37 to 2.62) and of non-Hodgkin lymphoma (NMZL OR = 2.82, 95% CI = 1.33 to 5.98), permanent hairdye use (SMZL OR = 6.59, 95% CI = 1.54 to 28.17), and occupation as a metalworker (NMZL OR = 3.56, 95% CI = 1.67 to 7.58). Reduced risks were observed with consumption of any alcohol (EMZL fourth quartile OR = 0.48, 95% CI = 0.28 to 0.82) and lower consumption of wine (NMZL first to third quartile ORs < 0.45) compared with nondrinkers, and occupation as a teacher (EMZL OR = 0.58, 95% CI = 0.37 to 0.88).CONCLUSION: Our results provide new data suggesting etiologic heterogeneity across MZL subtypes although a common risk of MZL associated with B-cell activating autoimmune conditions was found.

U2 - 10.1093/jncimonographs/lgu011

DO - 10.1093/jncimonographs/lgu011

M3 - Article

C2 - 25174026

SN - 1052-6773

VL - 2014

SP - 52

EP - 65

JO - Journal of the National Cancer Institute. Monographs

JF - Journal of the National Cancer Institute. Monographs

IS - 48

ER -