TY - JOUR
T1 - Melanocortin 1 receptor (MC1R), pigmentary characteristics and sun exposure
T2 - Findings from a case-control study of diffuse large B-cell and follicular lymphoma
AU - Kane, Eleanor V.
AU - Painter, Daniel Edwin
AU - Roman, Eve
AU - Allan, James
AU - Law, Graham
AU - Lightfoot, Tracy
PY - 2010/4
Y1 - 2010/4
N2 - The relationship between skin cancer and non-Hodgkin lymphoma (NHL) suggests common genetic, host or environmental causes. Ultraviolet radiation (UVR), pigmentary characteristics have been linked with both malignancies, and for skin cancer, the melanocortin 1 receptor (MC1R) which influences pigmentation has also been implicated. This paper reports on the relationship between MC1R, skin, hair and eye colour, time spent outdoors, and diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Persons carrying MC1R homozygote variant alleles at R151C, R160W, D294H and D84E were more likely to have fair skin, red hair and to spend less time outdoors than those who did not. The variant allele at V92M was associated with FL (odds ratio (OR) = 1.61, 95% confidence interval (CI) 1.08-2.39) and the r:wild type genotype with DLBCL (OR = 0.58, 95% CI 0.38-0.89). Interactions between MC1R genotypes and skin colour influenced DLBCL risk: the RR genotype increased risk in individuals with medium or dark skin, based on 5 cases and no controls, but decreased risk among those of fair skin. On the whole, DLBCL and FL risk were not related to genetic variation in MC1R, pigmentation or time spent outdoors. (C) 2010 Elsevier Ltd. All rights reserved.
AB - The relationship between skin cancer and non-Hodgkin lymphoma (NHL) suggests common genetic, host or environmental causes. Ultraviolet radiation (UVR), pigmentary characteristics have been linked with both malignancies, and for skin cancer, the melanocortin 1 receptor (MC1R) which influences pigmentation has also been implicated. This paper reports on the relationship between MC1R, skin, hair and eye colour, time spent outdoors, and diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Persons carrying MC1R homozygote variant alleles at R151C, R160W, D294H and D84E were more likely to have fair skin, red hair and to spend less time outdoors than those who did not. The variant allele at V92M was associated with FL (odds ratio (OR) = 1.61, 95% confidence interval (CI) 1.08-2.39) and the r:wild type genotype with DLBCL (OR = 0.58, 95% CI 0.38-0.89). Interactions between MC1R genotypes and skin colour influenced DLBCL risk: the RR genotype increased risk in individuals with medium or dark skin, based on 5 cases and no controls, but decreased risk among those of fair skin. On the whole, DLBCL and FL risk were not related to genetic variation in MC1R, pigmentation or time spent outdoors. (C) 2010 Elsevier Ltd. All rights reserved.
KW - Non-Hodgkin lymphoma
KW - Epidemiology
KW - Melanocortin 1 receptor
KW - Ultraviolet radiation
KW - NON-HODGKIN-LYMPHOMA
KW - OCCUPATIONAL SUNLIGHT EXPOSURE
KW - 2ND PRIMARY NEOPLASMS
KW - ULTRAVIOLET-RADIATION
KW - SKIN-CANCER
KW - RED HAIR
KW - FAIR SKIN
KW - VITAMIN-D
KW - RISK
KW - POPULATION
UR - http://www.scopus.com/inward/record.url?scp=77950461682&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2010.01.005
DO - 10.1016/j.canep.2010.01.005
M3 - Article
VL - 34
SP - 136
EP - 141
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 2
ER -