Mesenchymal stem cells from biology to therapy

David Kuntin; Paul Genever

doi:10.1042/ETLS20200303

Mesenchymal stem cells from biology to therapy

David Kuntin, Paul Genever^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Mesenchymal stem cells are as fascinating as they are enigmatic. They appear capable of performing a wide array of functions that cross skeletal biology, immunology and haematology. As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions. However, these cells lack unique markers and are hard to identify and isolate as pure cell populations. They are often grown in laboratories using basic and undefined culture conditions. We cannot even agree on their name. While mesenchymal stem cells may lack the developmental understanding and defined differentiation hierarchies of their more illustrious stem cell cousins, they offer a compelling scientific challenge. In depth understanding of mesenchymal stem cell biology will enable us to exploit fully one of the most clinically valuable cell sources.

Original language	English
Pages (from-to)	539-548
Number of pages	10
Journal	Emerging Topics in Life Sciences
Volume	5
Issue number	4
Early online date	6 Aug 2021
DOIs	https://doi.org/10.1042/ETLS20200303
Publication status	Published - Oct 2021

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10.1042/ETLS20200303Licence: CC BY

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© 2021 The Author(s).
Final published version, 1.04 MBLicence: CC BY

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AB - Mesenchymal stem cells are as fascinating as they are enigmatic. They appear capable of performing a wide array of functions that cross skeletal biology, immunology and haematology. As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions. However, these cells lack unique markers and are hard to identify and isolate as pure cell populations. They are often grown in laboratories using basic and undefined culture conditions. We cannot even agree on their name. While mesenchymal stem cells may lack the developmental understanding and defined differentiation hierarchies of their more illustrious stem cell cousins, they offer a compelling scientific challenge. In depth understanding of mesenchymal stem cell biology will enable us to exploit fully one of the most clinically valuable cell sources.

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Mesenchymal stem cells from biology to therapy

Abstract

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