Mesoporous Structured Silica – An improved catalyst for direct amide synthesis and its application to continuous flow processing

TY - JOUR

T1 - Mesoporous Structured Silica – An improved catalyst for direct amide synthesis and its application to continuous flow processing

AU - Farmer, Thomas James

AU - MacQuarrie, Duncan James

AU - Clark, James Hanley

AU - Breeden, Simon William

AU - Comerford, James William

PY - 2012/10/5

Y1 - 2012/10/5

N2 - We recently published details of an effective, reusable and benign heterogeneous amidation catalyst based on thermal treatment of amorphous K60 silica, however the loading of catalyst required was high for some reactions. We report herein our further development of a series of heterogeneous catalysts based on structured silica (SBA) that retain all the green credentials of the previously described amorphous silica, but with increased efficiency. These catalysts were then utilised in continuous flow systems, achieving excellent conversions with dramatically reduced reaction times.

AB - We recently published details of an effective, reusable and benign heterogeneous amidation catalyst based on thermal treatment of amorphous K60 silica, however the loading of catalyst required was high for some reactions. We report herein our further development of a series of heterogeneous catalysts based on structured silica (SBA) that retain all the green credentials of the previously described amorphous silica, but with increased efficiency. These catalysts were then utilised in continuous flow systems, achieving excellent conversions with dramatically reduced reaction times.

UR - http://www.scopus.com/inward/record.url?scp=84869810458&partnerID=8YFLogxK

M3 - Article

SN - 1424-6376

VL - 2012

SP - 282

EP - 293

JO - ARKIVOC

JF - ARKIVOC

IS - vii

ER -