Metabolic regulation of circadian clocks

Michael J. Haydon; Timothy J. Hearn; Laura J. Bell; Matthew A. Hannah; Alex A. R. Webb

doi:10.1016/j.semcdb.2013.03.007

Metabolic regulation of circadian clocks

Michael J. Haydon, Timothy J. Hearn, Laura J. Bell, Matthew A. Hannah, Alex A. R. Webb

CNAP

Research output: Contribution to journal › Literature review › peer-review

Abstract

Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.

Original language	English
Pages (from-to)	414-421
Number of pages	8
Journal	Seminars in cell & developmental biology
Volume	24
Issue number	5
Early online date	26 Mar 2013
DOIs	https://doi.org/10.1016/j.semcdb.2013.03.007
Publication status	Published - May 2013

Bibliographical note

Keywords

Circadian
Metabolism
Sugar
NAD
ROS
Arabidopsis

Access to Document

10.1016/j.semcdb.2013.03.007

Cite this

@article{d2079a9766de411b822f1191421e4798,

title = "Metabolic regulation of circadian clocks",

abstract = "Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.",

keywords = "Circadian, Metabolism, Sugar, NAD, ROS, Arabidopsis",

author = "Haydon, {Michael J.} and Hearn, {Timothy J.} and Bell, {Laura J.} and Hannah, {Matthew A.} and Webb, {Alex A. R.}",

note = "{\textcopyright} 2013 Elsevier Ltd",

year = "2013",

month = may,

doi = "10.1016/j.semcdb.2013.03.007",

language = "English",

volume = "24",

pages = "414--421",

journal = "Seminars in cell & developmental biology",

issn = "1084-9521",

publisher = "Academic Press",

number = "5",

}

TY - JOUR

T1 - Metabolic regulation of circadian clocks

AU - Haydon, Michael J.

AU - Hearn, Timothy J.

AU - Bell, Laura J.

AU - Hannah, Matthew A.

AU - Webb, Alex A. R.

PY - 2013/5

Y1 - 2013/5

N2 - Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.

AB - Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.

KW - Circadian

KW - Metabolism

KW - Sugar

KW - NAD

KW - ROS

KW - Arabidopsis

U2 - 10.1016/j.semcdb.2013.03.007

DO - 10.1016/j.semcdb.2013.03.007

M3 - Literature review

C2 - 23538134

SN - 1084-9521

VL - 24

SP - 414

EP - 421

JO - Seminars in cell & developmental biology

JF - Seminars in cell & developmental biology

IS - 5

ER -