Metabolic regulation of circadian clocks

Michael J. Haydon, Timothy J. Hearn, Laura J. Bell, Matthew A. Hannah, Alex A. R. Webb

Research output: Contribution to journalLiterature reviewpeer-review


Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.
Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalSeminars in cell & developmental biology
Issue number5
Early online date26 Mar 2013
Publication statusPublished - May 2013

Bibliographical note

© 2013 Elsevier Ltd


  • Circadian
  • Metabolism
  • Sugar
  • NAD
  • ROS
  • Arabidopsis

Cite this