Metabolic regulation of circadian clocks

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JournalSeminars in cell & developmental biology
DateE-pub ahead of print - 26 Mar 2013
DatePublished (current) - May 2013
Issue number5
Volume24
Number of pages8
Pages (from-to)414-421
Early online date26/03/13
Original languageEnglish

Abstract

Circadian clocks are 24-h timekeeping mechanisms, which have evolved in plants, animals, fungi and bacteria to anticipate changes in light and temperature associated with the rotation of the Earth. The current paradigm to explain how biological clocks provide timing information is based on multiple interlocking transcription-translation negative feedback loops (TTFL), which drive rhythmic gene expression and circadian behaviour of growth and physiology. Metabolism is an important circadian output, which in plants includes photosynthesis, starch metabolism, nutrient assimilation and redox homeostasis. There is increasing evidence in a range of organisms that these metabolic outputs can also contribute to circadian timing and might also comprise independent circadian oscillators. In this review, we summarise the mechanisms of circadian regulation of metabolism by TTFL and consider increasing evidence that rhythmic metabolism contributes to the circadian network. We highlight how this might be relevant to plant circadian clock function.

Bibliographical note

© 2013 Elsevier Ltd

    Research areas

  • Circadian, Metabolism, Sugar, NAD, ROS, Arabidopsis

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