By the same authors

From the same journal

From the same journal

Methods to assess cost effectiveness and value of further research when data are sparse: Negative-Pressure Wound Therapy for Severe Pressure Ulcers

Research output: Contribution to journalArticlepeer-review

Standard

Methods to assess cost effectiveness and value of further research when data are sparse : Negative-Pressure Wound Therapy for Severe Pressure Ulcers. / O Soares, Marta; Dumville, Jo; Ashby, Rebecca Louise; Iglesias Urrutia, Cynthia Paola; Bojke, Laura; Adderley, Una Jane; McGinnis, Elizabeth; Stubbs, Nikki; Torgerson, David John; Claxton, Karl Philip; Cullum, Nicky.

In: Medical Decision Making, Vol. 33, No. 3, 04.2013, p. 415-436.

Research output: Contribution to journalArticlepeer-review

Harvard

O Soares, M, Dumville, J, Ashby, RL, Iglesias Urrutia, CP, Bojke, L, Adderley, UJ, McGinnis, E, Stubbs, N, Torgerson, DJ, Claxton, KP & Cullum, N 2013, 'Methods to assess cost effectiveness and value of further research when data are sparse: Negative-Pressure Wound Therapy for Severe Pressure Ulcers', Medical Decision Making, vol. 33, no. 3, pp. 415-436. https://doi.org/10.1177/0272989X12451058

APA

O Soares, M., Dumville, J., Ashby, R. L., Iglesias Urrutia, C. P., Bojke, L., Adderley, U. J., McGinnis, E., Stubbs, N., Torgerson, D. J., Claxton, K. P., & Cullum, N. (2013). Methods to assess cost effectiveness and value of further research when data are sparse: Negative-Pressure Wound Therapy for Severe Pressure Ulcers. Medical Decision Making, 33(3), 415-436. https://doi.org/10.1177/0272989X12451058

Vancouver

O Soares M, Dumville J, Ashby RL, Iglesias Urrutia CP, Bojke L, Adderley UJ et al. Methods to assess cost effectiveness and value of further research when data are sparse: Negative-Pressure Wound Therapy for Severe Pressure Ulcers. Medical Decision Making. 2013 Apr;33(3):415-436. https://doi.org/10.1177/0272989X12451058

Author

O Soares, Marta ; Dumville, Jo ; Ashby, Rebecca Louise ; Iglesias Urrutia, Cynthia Paola ; Bojke, Laura ; Adderley, Una Jane ; McGinnis, Elizabeth ; Stubbs, Nikki ; Torgerson, David John ; Claxton, Karl Philip ; Cullum, Nicky. / Methods to assess cost effectiveness and value of further research when data are sparse : Negative-Pressure Wound Therapy for Severe Pressure Ulcers. In: Medical Decision Making. 2013 ; Vol. 33, No. 3. pp. 415-436.

Bibtex - Download

@article{e2c720ef76ac4982b0430d261205215f,
title = "Methods to assess cost effectiveness and value of further research when data are sparse: Negative-Pressure Wound Therapy for Severe Pressure Ulcers",
abstract = "Health care resources are scarce, and decisions have to be made about how to allocate funds. Often, these decisions are based on sparse or imperfect evidence. One such example is negative-pressure wound therapy (NPWT), which is a widely used treatment for severe pressure ulcers; however, there is currently no robust evidence that it is effective or cost-effective. This work considers the decision to adopt NPWT given a range of alternative treatments, using a decision analytic modeling approach. Literature searches were conducted to identify existing evidence on model parameters. Given the limited evidence base, a second source of evidence, beliefs elicited from experts, was used. Judgments from experts on relevant (uncertain) quantities were obtained through a formal elicitation exercise. Additionally, data derived from a pilot trial were also used to inform the model. The 3 sources of evidence were collated, and the impact of each on cost-effectiveness was evaluated. An analysis of the value of further information indicated that a randomized controlled trial may be worthwhile in reducing decision uncertainty, where from a set of alternative designs, a 3-arm trial with longer follow-up was estimated to be the most efficient. The analyses presented demonstrate how allocation decisions about medical technologies can be explicitly informed when data are sparse and how this kind of analyses can be used to guide future research prioritization, not only indicating whether further research is worthwhile but what type of research is needed and how it should be designed.",
author = "{O Soares}, Marta and Jo Dumville and Ashby, {Rebecca Louise} and {Iglesias Urrutia}, {Cynthia Paola} and Laura Bojke and Adderley, {Una Jane} and Elizabeth McGinnis and Nikki Stubbs and Torgerson, {David John} and Claxton, {Karl Philip} and Nicky Cullum",
year = "2013",
month = apr,
doi = "10.1177/0272989X12451058",
language = "English",
volume = "33",
pages = "415--436",
journal = "Medical Decision Making",
issn = "0272-989X",
publisher = "SAGE Publications",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Methods to assess cost effectiveness and value of further research when data are sparse

T2 - Negative-Pressure Wound Therapy for Severe Pressure Ulcers

AU - O Soares, Marta

AU - Dumville, Jo

AU - Ashby, Rebecca Louise

AU - Iglesias Urrutia, Cynthia Paola

AU - Bojke, Laura

AU - Adderley, Una Jane

AU - McGinnis, Elizabeth

AU - Stubbs, Nikki

AU - Torgerson, David John

AU - Claxton, Karl Philip

AU - Cullum, Nicky

PY - 2013/4

Y1 - 2013/4

N2 - Health care resources are scarce, and decisions have to be made about how to allocate funds. Often, these decisions are based on sparse or imperfect evidence. One such example is negative-pressure wound therapy (NPWT), which is a widely used treatment for severe pressure ulcers; however, there is currently no robust evidence that it is effective or cost-effective. This work considers the decision to adopt NPWT given a range of alternative treatments, using a decision analytic modeling approach. Literature searches were conducted to identify existing evidence on model parameters. Given the limited evidence base, a second source of evidence, beliefs elicited from experts, was used. Judgments from experts on relevant (uncertain) quantities were obtained through a formal elicitation exercise. Additionally, data derived from a pilot trial were also used to inform the model. The 3 sources of evidence were collated, and the impact of each on cost-effectiveness was evaluated. An analysis of the value of further information indicated that a randomized controlled trial may be worthwhile in reducing decision uncertainty, where from a set of alternative designs, a 3-arm trial with longer follow-up was estimated to be the most efficient. The analyses presented demonstrate how allocation decisions about medical technologies can be explicitly informed when data are sparse and how this kind of analyses can be used to guide future research prioritization, not only indicating whether further research is worthwhile but what type of research is needed and how it should be designed.

AB - Health care resources are scarce, and decisions have to be made about how to allocate funds. Often, these decisions are based on sparse or imperfect evidence. One such example is negative-pressure wound therapy (NPWT), which is a widely used treatment for severe pressure ulcers; however, there is currently no robust evidence that it is effective or cost-effective. This work considers the decision to adopt NPWT given a range of alternative treatments, using a decision analytic modeling approach. Literature searches were conducted to identify existing evidence on model parameters. Given the limited evidence base, a second source of evidence, beliefs elicited from experts, was used. Judgments from experts on relevant (uncertain) quantities were obtained through a formal elicitation exercise. Additionally, data derived from a pilot trial were also used to inform the model. The 3 sources of evidence were collated, and the impact of each on cost-effectiveness was evaluated. An analysis of the value of further information indicated that a randomized controlled trial may be worthwhile in reducing decision uncertainty, where from a set of alternative designs, a 3-arm trial with longer follow-up was estimated to be the most efficient. The analyses presented demonstrate how allocation decisions about medical technologies can be explicitly informed when data are sparse and how this kind of analyses can be used to guide future research prioritization, not only indicating whether further research is worthwhile but what type of research is needed and how it should be designed.

UR - http://www.scopus.com/inward/record.url?scp=84875696245&partnerID=8YFLogxK

U2 - 10.1177/0272989X12451058

DO - 10.1177/0272989X12451058

M3 - Article

VL - 33

SP - 415

EP - 436

JO - Medical Decision Making

JF - Medical Decision Making

SN - 0272-989X

IS - 3

ER -