microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation

Daniel Yee; Mark C Coles; Dimitris Lagos

doi:10.3389/fimmu.2017.00104

microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation

Daniel Yee, Mark C Coles, Dimitris Lagos

Research output: Contribution to journal › Article › peer-review

Abstract

microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.

Original language	English
Article number	104
Number of pages	8
Journal	Frontiers in immunology
Volume	8
DOIs	https://doi.org/10.3389/fimmu.2017.00104
Publication status	Published - 9 Feb 2017

Bibliographical note

Keywords

Journal Article
Review

Access to Document

10.3389/fimmu.2017.00104

fimmu-08-00104
© 2017 Yee, Coles and Lagos.
Final published version, 645 KBLicence: CC BY

Cite this

@article{97f2274f8f01448a878cdffb7b81d145,

title = "microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation",

abstract = "microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.",

keywords = "Journal Article, Review",

author = "Daniel Yee and Coles, {Mark C} and Dimitris Lagos",

note = "{\textcopyright} 2017 Yee, Coles and Lagos.",

year = "2017",

month = feb,

day = "9",

doi = "10.3389/fimmu.2017.00104",

language = "English",

volume = "8",

journal = "Frontiers in immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - microRNAs in the Lymphatic Endothelium

T2 - Master Regulators of Lineage Plasticity and Inflammation

AU - Yee, Daniel

AU - Coles, Mark C

AU - Lagos, Dimitris

PY - 2017/2/9

Y1 - 2017/2/9

N2 - microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.

AB - microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.

KW - Journal Article

KW - Review

U2 - 10.3389/fimmu.2017.00104

DO - 10.3389/fimmu.2017.00104

M3 - Article

C2 - 28232833

SN - 1664-3224

VL - 8

JO - Frontiers in immunology

JF - Frontiers in immunology

M1 - 104

ER -