Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.: Developmental Cell

Motoyuki Itoh; Cheol-Hee Kim; Gregory Palardy; Takaya Oda; Yun-Jin Jiang; Donovan Maust; Sang-Yeob Yeo; Kevin Lorick; Gavin J Wright; Linda Ariza-McNaughton; Allan M Weissman; Julian Lewis; Settara C Chandrasekharappa; Ajay B Chitnis

doi:10.1016/s1534-5807(02)00409-4

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Developmental Cell

Motoyuki Itoh, Cheol-Hee Kim, Gregory Palardy, Takaya Oda, Yun-Jin Jiang, Donovan Maust, Sang-Yeob Yeo, Kevin Lorick, Gavin J Wright, Linda Ariza-McNaughton, Allan M Weissman, Julian Lewis, Settara C Chandrasekharappa, Ajay B Chitnis

Research output: Contribution to journal › Article › peer-review

Abstract

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.

Original language	English
Pages (from-to)	67-82
Number of pages	16
Journal	Developmental Cell
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/s1534-5807(02)00409-4
Publication status	Published - 2003

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10.1016/s1534-5807(02)00409-4

http://dx.doi.org/10.1016/s1534-5807(02)00409-4

Cite this

Itoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G. J., Ariza-McNaughton, L., Weissman, A. M., Lewis, J., Chandrasekharappa, S. C., & Chitnis, A. B. (2003). Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Developmental Cell. Developmental Cell, 4(1), 67-82. https://doi.org/10.1016/s1534-5807(02)00409-4

@article{a7d7dbf641124c1e9137303ceedff22a,

title = "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.: Developmental Cell",

abstract = "Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.",

author = "Motoyuki Itoh and Cheol-Hee Kim and Gregory Palardy and Takaya Oda and Yun-Jin Jiang and Donovan Maust and Sang-Yeob Yeo and Kevin Lorick and Wright, {Gavin J} and Linda Ariza-McNaughton and Weissman, {Allan M} and Julian Lewis and Chandrasekharappa, {Settara C} and Chitnis, {Ajay B}",

year = "2003",

doi = "10.1016/s1534-5807(02)00409-4",

language = "English",

volume = "4",

pages = "67--82",

journal = "Developmental Cell",

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publisher = "Cell Press",

number = "1",

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Itoh, M, Kim, C-H, Palardy, G, Oda, T, Jiang, Y-J, Maust, D, Yeo, S-Y, Lorick, K, Wright, GJ, Ariza-McNaughton, L, Weissman, AM, Lewis, J, Chandrasekharappa, SC & Chitnis, AB 2003, 'Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Developmental Cell', Developmental Cell, vol. 4, no. 1, pp. 67-82. https://doi.org/10.1016/s1534-5807(02)00409-4

TY - JOUR

T1 - Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

T2 - Developmental Cell

AU - Itoh, Motoyuki

AU - Kim, Cheol-Hee

AU - Palardy, Gregory

AU - Oda, Takaya

AU - Jiang, Yun-Jin

AU - Maust, Donovan

AU - Yeo, Sang-Yeob

AU - Lorick, Kevin

AU - Wright, Gavin J

AU - Ariza-McNaughton, Linda

AU - Weissman, Allan M

AU - Lewis, Julian

AU - Chandrasekharappa, Settara C

AU - Chitnis, Ajay B

PY - 2003

Y1 - 2003

N2 - Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.

AB - Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. These observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocytosis of the Notch extracellular domain by the signaling cell. This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells.

U2 - 10.1016/s1534-5807(02)00409-4

DO - 10.1016/s1534-5807(02)00409-4

M3 - Article

SN - 1534-5807

VL - 4

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JO - Developmental Cell

JF - Developmental Cell

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