Miniature Untethered EEG Recorder Improves Advanced Neuroscience Methodologies

TY - JOUR

T1 - Miniature Untethered EEG Recorder Improves Advanced Neuroscience Methodologies

AU - Crispin-Bailey, Christopher

AU - Austin, James

AU - Moulds, Anthony

AU - Platt, Bettina

AU - Crouch, Barry

N1 - (c) 2019 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.

PY - 2019/8/14

Y1 - 2019/8/14

N2 - Rodent electroencephalography (EEG) in preclinical research is frequently conducted in behaving animals. However, the difficulty inherent in identifying EEG epochs associated with a particular behavior or cue is a significant obstacle to more efficient analysis. In this paper we highlight a new solution, using infrared event stamping to accurately synchronize EEG, recorded from superficial sites above the hippocampus and prefrontal cortex, with video motion tracking data in a transgenic Alzheimer’s disease (AD) mouse model. Epochs capturing specific behaviors were automatically identified and extracted prior to further analysis. This was achieved by the novel design of a ultra- miniature wearable EEG recorder, the NAT-1 device, and its in- situ IR recording module. The device is described in detail, and its contribution to enabling new neuroscience is demonstrated.

AB - Rodent electroencephalography (EEG) in preclinical research is frequently conducted in behaving animals. However, the difficulty inherent in identifying EEG epochs associated with a particular behavior or cue is a significant obstacle to more efficient analysis. In this paper we highlight a new solution, using infrared event stamping to accurately synchronize EEG, recorded from superficial sites above the hippocampus and prefrontal cortex, with video motion tracking data in a transgenic Alzheimer’s disease (AD) mouse model. Epochs capturing specific behaviors were automatically identified and extracted prior to further analysis. This was achieved by the novel design of a ultra- miniature wearable EEG recorder, the NAT-1 device, and its in- situ IR recording module. The device is described in detail, and its contribution to enabling new neuroscience is demonstrated.

KW - Experimental neuroscience

KW - EEG recording

KW - low-power sensors

U2 - 10.1109/TBCAS.2019.2935298

DO - 10.1109/TBCAS.2019.2935298

M3 - Article

SN - 1932-4545

VL - 13

SP - 1101

EP - 1111

JO - IEEE Transactions on Biomedical Circuits and Systems

JF - IEEE Transactions on Biomedical Circuits and Systems

IS - 5

ER -