Modelling cell signalling and differentiation in the urothelium

P J Woodroffe, J R King, C L Varley, J Southgate

Research output: Contribution to journalArticlepeer-review


Urothelial cells line the bladder. If the urothelium is damaged, it is vital that it repairs itself quickly. Experimental results shedding light on how this repair process works are presented, revealing in particular the dependence of the response on the length of time for which the drug Troglitazone (TZ) is applied. A simple mathematical model for the basic mechanism (comprising ordinary differential equations) is then developed and analysed, seeking specifically to clarify and quantify the mechanisms governing the dependence of the cell differentiation response on the TZ administration time, rather than providing a comprehensive model of differentiation. Through biologically justified simplifications, analysis reveals that the model gives results in accord with the experimental observations, and suggests new experiments that may aid further understanding. Directions in which this preliminary modelling of the PPARgamma (peroxisome proliferator activated receptor gamma) pathway could be usefully extended are also indicated. (C) 2004 Society for Mathematical Biology. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)369-389
Number of pages21
JournalBulletin of Mathematical Biology
Issue number2
Publication statusPublished - Mar 2005



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