Modelling the tunability of early T cell signalling events

Nick D. L. Owens; Jon Timmis; Andrew Greensted; Andy Tyrrell

Modelling the tunability of early T cell signalling events

Nick D. L. Owens, Jon Timmis, Andrew Greensted, Andy Tyrrell

Research output: Contribution to journal › Article › peer-review

Abstract

The Tunable Activation Threshold hypothesis of T Cells is investigated through computational modelling of T cell signalling pathways. Modelling techniques involving the pi-calculus and the PRISM model checker are presented, and are applied to produce a stochastic model of T cell signalling. Initial results which demonstrate tuning of T cells are presented.

Original language	English
Pages (from-to)	12-23
Number of pages	12
Journal	7th International Conference on Artificial Immune Systems (ICARIS)
Volume	5132
Publication status	Published - Aug 2008

Keywords

STOCHASTIC-PI-CALCULUS
LIGAND DISCRIMINATION
SIMULATION
RESPONSES
ANTIGEN

Cite this

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title = "Modelling the tunability of early T cell signalling events",

abstract = "The Tunable Activation Threshold hypothesis of T Cells is investigated through computational modelling of T cell signalling pathways. Modelling techniques involving the pi-calculus and the PRISM model checker are presented, and are applied to produce a stochastic model of T cell signalling. Initial results which demonstrate tuning of T cells are presented.",

keywords = "STOCHASTIC-PI-CALCULUS, LIGAND DISCRIMINATION, SIMULATION, RESPONSES, ANTIGEN",

author = "Owens, {Nick D. L.} and Jon Timmis and Andrew Greensted and Andy Tyrrell",

year = "2008",

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language = "English",

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T1 - Modelling the tunability of early T cell signalling events

AU - Owens, Nick D. L.

AU - Timmis, Jon

AU - Greensted, Andrew

AU - Tyrrell, Andy

PY - 2008/8

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N2 - The Tunable Activation Threshold hypothesis of T Cells is investigated through computational modelling of T cell signalling pathways. Modelling techniques involving the pi-calculus and the PRISM model checker are presented, and are applied to produce a stochastic model of T cell signalling. Initial results which demonstrate tuning of T cells are presented.

AB - The Tunable Activation Threshold hypothesis of T Cells is investigated through computational modelling of T cell signalling pathways. Modelling techniques involving the pi-calculus and the PRISM model checker are presented, and are applied to produce a stochastic model of T cell signalling. Initial results which demonstrate tuning of T cells are presented.

KW - STOCHASTIC-PI-CALCULUS

KW - LIGAND DISCRIMINATION

KW - SIMULATION

KW - RESPONSES

KW - ANTIGEN

UR - http://www.scopus.com/inward/record.url?scp=51049122630&partnerID=8YFLogxK

M3 - Article

VL - 5132

SP - 12

EP - 23

JO - 7th International Conference on Artificial Immune Systems (ICARIS)

JF - 7th International Conference on Artificial Immune Systems (ICARIS)

ER -

Modelling the tunability of early T cell signalling events

Abstract

Keywords

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