By the same authors

From the same journal

From the same journal

Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade

Research output: Contribution to journalArticlepeer-review

Full text download(s)

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalOrganic Letters
DateE-pub ahead of print - 15 Jan 2020
Original languageEnglish

Abstract

The polycyclic core of the akuammiline alkaloids can be synthesized from simple tryptamine and tryptophol derivatives via a Ag(I)-catalyzed enantioselective dearomative cyclization cascade sequence. The complex tetracyclic scaffolds are prepared via a rapid, versatile, three-step modular synthesis from simple commercially available indole derivatives in high yields and enantiomeric excess (up to 99% yield and >99% ee).

Bibliographical note

© 2020 American Chemical Society.

Projects

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations