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Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade
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Publication details
| Journal | Organic Letters |
|---|---|
| Date | Accepted/In press - 15 Jan 2020 |
| Date | E-pub ahead of print - 15 Jan 2020 |
| Date | Published (current) - 7 Feb 2020 |
| Issue number | 3 |
| Volume | 22 |
| Number of pages | 7 |
| Pages (from-to) | 1175–1181 |
| Early online date | 15/01/20 |
| Original language | English |
Abstract
The polycyclic core of the akuammiline alkaloids can be synthesized from simple tryptamine and tryptophol derivatives via a Ag(I)-catalyzed enantioselective dearomative cyclization cascade sequence. The complex tetracyclic scaffolds are prepared via a rapid, versatile, three-step modular synthesis from simple commercially available indole derivatives in high yields and enantiomeric excess (up to 99% yield and >99% ee).
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© 2020 American Chemical Society.
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