Molecular antimicrobial susceptibility testing in sepsis

Ignacio Martin-Loeches; João Gonçalves Pereira; Tee Keat Teoh; Gavin Barlow; Laurent Dortet; Enitan D Carrol; Ulrike Olgemöller; Sara E Boyd; Julien Textoris

doi:10.2217/fmb-2023-0128

Molecular antimicrobial susceptibility testing in sepsis

Ignacio Martin-Loeches, João Gonçalves Pereira, Tee Keat Teoh, Gavin Barlow, Laurent Dortet, Enitan D Carrol, Ulrike Olgemöller, Sara E Boyd, Julien Textoris

The Hull York Medical School

Research output: Contribution to journal › Review article › peer-review

Abstract

Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their diagnostic capacity by using novel molecular methods that make obtaining quicker, more precise results possible. The authors discuss and critically assess the merits and drawbacks of molecular testing and the added value of these tests, including the shift turnaround time, the implication for clinicians' decisions, gaps in knowledge, future research directions and novel insights or innovations. The field of antimicrobial molecular testing has seen several novel insights and innovations to improve the diagnosis and management of infectious diseases.

Original language	English
Pages (from-to)	61-72
Number of pages	12
Journal	Future microbiology
Volume	19
DOIs	https://doi.org/10.2217/fmb-2023-0128
Publication status	Published - 5 Jan 2024

Keywords

Humans
Anti-Bacterial Agents/pharmacology
Sepsis/diagnosis
Bacteria/genetics
Anti-Infective Agents/pharmacology
Time Factors

Access to Document

10.2217/fmb-2023-0128

Cite this

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title = "Molecular antimicrobial susceptibility testing in sepsis",

abstract = "Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their diagnostic capacity by using novel molecular methods that make obtaining quicker, more precise results possible. The authors discuss and critically assess the merits and drawbacks of molecular testing and the added value of these tests, including the shift turnaround time, the implication for clinicians' decisions, gaps in knowledge, future research directions and novel insights or innovations. The field of antimicrobial molecular testing has seen several novel insights and innovations to improve the diagnosis and management of infectious diseases.",

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AU - Martin-Loeches, Ignacio

AU - Pereira, João Gonçalves

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AU - Dortet, Laurent

AU - Carrol, Enitan D

AU - Olgemöller, Ulrike

AU - Boyd, Sara E

AU - Textoris, Julien

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AB - Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their diagnostic capacity by using novel molecular methods that make obtaining quicker, more precise results possible. The authors discuss and critically assess the merits and drawbacks of molecular testing and the added value of these tests, including the shift turnaround time, the implication for clinicians' decisions, gaps in knowledge, future research directions and novel insights or innovations. The field of antimicrobial molecular testing has seen several novel insights and innovations to improve the diagnosis and management of infectious diseases.

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KW - Anti-Bacterial Agents/pharmacology

KW - Sepsis/diagnosis

KW - Bacteria/genetics

KW - Anti-Infective Agents/pharmacology

KW - Time Factors

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