Mono-benzyl substituted cis, cis-1,3,5-triaminocyclohexanes

S J  Archibald; A K  Nairn; P  Timmins; P H  Walton

doi:10.1016/j.tetlet.2005.07.112

Mono-benzyl substituted cis, cis-1,3,5-triaminocyclohexanes

S J Archibald, A K Nairn, P Timmins, P H Walton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Unsymmetrical derivatives of the versatile molecule cis, cis-1,3,5-triaminocyclohexane (tach) have been prepared using a new metal-promoted synthesis to give the mono N-substituted tach ligands. This new method enables the synthesis of these molecules selectively and in good yields and purity. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	6441-6443
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2005.07.112
Publication status	Published - 19 Sept 2005

Keywords

triaminocyclohexane
nickel
biomimetic
ANTI-ANGIOGENIC THERAPY
N-PYRIDYL DERIVATIVES
COPPER(II) COMPLEX
TRIAMINE LIGANDS
CIS,CIS-1,3,5-TRIAMINOCYCLOHEXANE
AGENTS
CYTOTOXICITY
HYDROLYSIS
CHELATION
BINDING

Access to Document

10.1016/j.tetlet.2005.07.112

Cite this

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title = "Mono-benzyl substituted cis, cis-1,3,5-triaminocyclohexanes",

abstract = "Unsymmetrical derivatives of the versatile molecule cis, cis-1,3,5-triaminocyclohexane (tach) have been prepared using a new metal-promoted synthesis to give the mono N-substituted tach ligands. This new method enables the synthesis of these molecules selectively and in good yields and purity. (c) 2005 Elsevier Ltd. All rights reserved.",

keywords = "triaminocyclohexane, nickel, biomimetic, ANTI-ANGIOGENIC THERAPY, N-PYRIDYL DERIVATIVES, COPPER(II) COMPLEX, TRIAMINE LIGANDS, CIS,CIS-1,3,5-TRIAMINOCYCLOHEXANE, AGENTS, CYTOTOXICITY, HYDROLYSIS, CHELATION, BINDING",

author = "Archibald, {S J} and Nairn, {A K} and P Timmins and Walton, {P H}",

year = "2005",

month = sep,

day = "19",

doi = "10.1016/j.tetlet.2005.07.112",

language = "English",

volume = "46",

pages = "6441--6443",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "38",

}

TY - JOUR

T1 - Mono-benzyl substituted cis, cis-1,3,5-triaminocyclohexanes

AU - Archibald, S J

AU - Nairn, A K

AU - Timmins, P

AU - Walton, P H

PY - 2005/9/19

Y1 - 2005/9/19

N2 - Unsymmetrical derivatives of the versatile molecule cis, cis-1,3,5-triaminocyclohexane (tach) have been prepared using a new metal-promoted synthesis to give the mono N-substituted tach ligands. This new method enables the synthesis of these molecules selectively and in good yields and purity. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Unsymmetrical derivatives of the versatile molecule cis, cis-1,3,5-triaminocyclohexane (tach) have been prepared using a new metal-promoted synthesis to give the mono N-substituted tach ligands. This new method enables the synthesis of these molecules selectively and in good yields and purity. (c) 2005 Elsevier Ltd. All rights reserved.

KW - triaminocyclohexane

KW - nickel

KW - biomimetic

KW - ANTI-ANGIOGENIC THERAPY

KW - N-PYRIDYL DERIVATIVES

KW - COPPER(II) COMPLEX

KW - TRIAMINE LIGANDS

KW - CIS,CIS-1,3,5-TRIAMINOCYCLOHEXANE

KW - AGENTS

KW - CYTOTOXICITY

KW - HYDROLYSIS

KW - CHELATION

KW - BINDING

U2 - 10.1016/j.tetlet.2005.07.112

DO - 10.1016/j.tetlet.2005.07.112

M3 - Article

SN - 0040-4039

VL - 46

SP - 6441

EP - 6443

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -