Morphological Control of Self-Assembled Multivalent (SAMul) Heparin Binding in Highly Competitive Media

Ana Campo Rodrigo, Stephen Bromfield, Erik Laurini, Paola Posocco, Sabrina Pricl, David Kelham Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Tuning molecular structures of self-assembling multivalent (SAMul) dendritic cationic lipopeptides controls the self-assembled morphology. In buffer, spherical micelles formed by higher generation systems bind polyanionic heparin better than worm-like micelles formed by lower generation systems. In human serum, the binding of spherical micelles to heparin is adversely affected, while worm-like micelles maintain their relative binding ability.
Original languageEnglish
Pages (from-to)6335-6338
JournalChemical Communications
Volume53
DOIs
Publication statusPublished - 30 May 2017

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