@article{f30abc371cb84e59ad873705429f4ae3,
title = "Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids",
abstract = "The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study/methods, Genotype, Humans, Life Style, Linkage Disequilibrium/genetics, Lipids/blood, Male, Middle Aged, Smoking/blood, Young Adult",
author = "{Understanding Society Scientific Group} and {Lifelines Cohort} and {COGENT-Kidney Consortium} and {EPIC-Interact Consortium} and Bentley, {Amy R.} and Sung, {Yun J.} and Brown, {Michael R.} and Winkler, {Thomas W.} and Kraja, {Aldi T.} and Ioanna Ntalla and Karen Schwander and Chasman, {Daniel I.} and Elise Lim and Xuan Deng and Xiuqing Guo and Jingmin Liu and Yingchang Lu and Cheng, {Ching Yu} and Xueling Sim and Dina Vojinovic and Huffman, {Jennifer E.} and Musani, {Solomon K.} and Changwei Li and Feitosa, {Mary F.} and Richard, {Melissa A.} and Raymond Noordam and Jenna Baker and Guanjie Chen and Hugues Aschard and Bartz, {Traci M.} and Jingzhong Ding and Rajkumar Dorajoo and Manning, {Alisa K.} and Tuomo Rankinen and Smith, {Albert V.} and Tajuddin, {Salman M.} and Wei Zhao and Mariaelisa Graff and Maris Alver and Mathilde Boissel and Chai, {Jin Fang} and Xu Chen and Jasmin Divers and Evangelos Evangelou and Chuan Gao and Anuj Goel and Yanick Hagemeijer and Harris, {Sarah E.} and Hartwig, {Fernando P.} and Meian He and Horimoto, {Andrea R.V.R.} and Muhammad Riaz and Saima Afaq and Jie Zhou",
note = "Publisher Copyright: {\textcopyright} 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",
year = "2019",
month = apr,
day = "1",
doi = "10.1038/s41588-019-0378-y",
language = "English",
volume = "51",
pages = "636--648",
journal = "Nature genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "4",
}