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Multidomain hybrid hydrogels: Spatially resolved photopatterned synthetic nanomaterials combining polymer and low-molecular-weight gelators

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JournalAngewandte Chemie International Edition
DateE-pub ahead of print - 21 Aug 2014
DatePublished (current) - 10 Nov 2014
Issue number46
Volume53
Number of pages5
Pages (from-to)12461-12465
Early online date21/08/14
Original languageEnglish

Abstract

A simple approach to a patterned multidomain gel is reported, combining a pH-responsive low-molecular-weight gelator (LMWG) and a photoinducible polymer gelator (PG). Using SEM (scanning electron microscopy), NMR spectroscopy, and CD, we demonstrate that self-assembly of the LMWG network occurs in the presence of the PG network, but that the PG has an influence on LMWG assembly kinetics and morphology. The application of a mask during photoirradiation allows patterning of the PG network; we define the resulting system as a "multidomain gel"-one domain consists of a LMWG, whereas the patterned region contains both LMWG and PG networks. The different domains have different properties with regard to diffusion of small molecules, and both gelator networks can control diffusion rates to give systems capable of controlled release. Such materials may have future applications in multikinetic control of drug release, or as patterned scaffolds for directed tissue engineering.

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© 2013, Wiely-VCH Verlag GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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