Multiple model simulation: modelling cell division and differentiation in the prostate

Research output: Contribution to conferencePaper

Standard

Multiple model simulation : modelling cell division and differentiation in the prostate. / Droop, Alastair; Garnett, Philip; Polack, Fiona A. C.; Stepney, Susan.

2011.

Research output: Contribution to conferencePaper

Harvard

Droop, A, Garnett, P, Polack, FAC & Stepney, S 2011, 'Multiple model simulation: modelling cell division and differentiation in the prostate'. <http://www-users.cs.york.ac.uk/~susan/bib/ss/nonstd/cosmos11-pmodel.htm>

APA

Droop, A., Garnett, P., Polack, F. A. C., & Stepney, S. (2011). Multiple model simulation: modelling cell division and differentiation in the prostate. http://www-users.cs.york.ac.uk/~susan/bib/ss/nonstd/cosmos11-pmodel.htm

Vancouver

Droop A, Garnett P, Polack FAC, Stepney S. Multiple model simulation: modelling cell division and differentiation in the prostate. 2011.

Author

Droop, Alastair ; Garnett, Philip ; Polack, Fiona A. C. ; Stepney, Susan. / Multiple model simulation : modelling cell division and differentiation in the prostate.

Bibtex - Download

@conference{8ba938e9dd834229a43b3c3823d99969,
title = "Multiple model simulation: modelling cell division and differentiation in the prostate",
abstract = "We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.",
author = "Alastair Droop and Philip Garnett and Polack, {Fiona A. C.} and Susan Stepney",
year = "2011",
language = "Undefined/Unknown",

}

RIS (suitable for import to EndNote) - Download

TY - CONF

T1 - Multiple model simulation

T2 - modelling cell division and differentiation in the prostate

AU - Droop, Alastair

AU - Garnett, Philip

AU - Polack, Fiona A. C.

AU - Stepney, Susan

PY - 2011

Y1 - 2011

N2 - We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.

AB - We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.

M3 - Paper

ER -