Projects per year
Abstract
We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.
| Original language | Undefined/Unknown |
|---|---|
| Publication status | Published - 2011 |
Projects
- 3 Finished
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C2D2 research 1a - Data and simulation of the dynamics of stem cell amplification in prostate disease development and control (Benign Prostatic Hyperplasia)
Polack, F. A. C. (Principal investigator), Maitland, N. J. (Co-investigator) & Stepney, S. (Co-investigator)
1/03/12 → 30/09/12
Project: Other project › Other internal award
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TRANSIT: TRANSIT
Caves, L. (Principal investigator), Delius, G. W. (Co-investigator), Sebald, A. (Co-investigator), Stepney, S. (Co-investigator), Timmis, J. (Co-investigator) & Wood, A. J. (Co-investigator)
7/01/08 → 6/01/11
Project: Research project (funded) › Research
File -
Cosmos: Complex Systems Modelling and Simulation
Stepney, S. (Principal investigator)
1/10/07 → 31/03/12
Project: Research project (funded) › Research