Projects per year
We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.
|Publication status||Published - 2011|
- 3 Finished
C2D2 research 1a - Data and simulation of the dynamics of stem cell amplification in prostate disease development and control (Benign Prostatic Hyperplasia)
1/03/12 → 30/09/12
Project: Other project › Other internal award