Multiple model simulation: modelling cell division and differentiation in the prostate

TY - CONF

T1 - Multiple model simulation

T2 - modelling cell division and differentiation in the prostate

AU - Droop, Alastair

AU - Garnett, Philip

AU - Polack, Fiona A. C.

AU - Stepney, Susan

PY - 2011

Y1 - 2011

N2 - We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.

AB - We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.

M3 - Paper

ER -