Projects per year
We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.
|Publication status||Published - 2011|
- 3 Finished
C2D2 research 1a - Data and simulation of the dynamics of stem cell amplification in prostate disease development and control (Benign Prostatic Hyperplasia)
Polack, F. A. C., Maitland, N. J. & Stepney, S.
1/03/12 → 30/09/12
Project: Other project › Other internal award
Caves, L., Delius, G. W., Sebald, A., Stepney, S., Timmis, J. & Wood, A. J.
7/01/08 → 6/01/11
Project: Research project (funded) › ResearchFile
Cosmos: Complex Systems Modelling and Simulation
1/10/07 → 31/03/12
Project: Research project (funded) › Research