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Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

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JournalBritish Journal of Haematology
DateAccepted/In press - 3 Nov 2016
DateE-pub ahead of print - 1 Feb 2017
DatePublished (current) - 1 Feb 2017
Number of pages5
Pages (from-to)1-5
Early online date1/02/17
Original languageEnglish

Abstract

Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012-2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ(2) = 13·8, P = 0·0002).

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© 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

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