Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Debra Howell; Alexandra Smith; Simon Appleton; Timothy Bagguley; Una Macleod; Gordon Cook; Russell Patmore; Eve Roman

doi:10.1111/bjh.14513

Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Debra Howell, Alexandra Smith, Simon Appleton, Timothy Bagguley, Una Macleod, Gordon Cook, Russell Patmore, Eve Roman

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ ² = 13·8, P = 0·0002).

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	British Journal of Haematology
Volume	177
Issue number	1
Early online date	1 Feb 2017
DOIs	https://doi.org/10.1111/bjh.14513
Publication status	Published - 28 Mar 2017

Bibliographical note

Keywords

Journal Article
multiple myeloma
emergency presentation
route to diagnosis
survival
clinical characteristics
Outcome Assessment (Health Care)
Humans
Middle Aged
Male
Multiple Myeloma/diagnosis
United Kingdom/epidemiology
Phenotype
Aged, 80 and over
Female
Aged
Disease Management
Population Surveillance

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10.1111/bjh.14513Licence: CC BY

Howell_et_al-2017-British_Journal_of_Haematology
© 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.
Final published version, 110 KBLicence: CC BY

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title = "Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study",

abstract = "Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ 2 = 13·8, P = 0·0002). ",

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author = "Debra Howell and Alexandra Smith and Simon Appleton and Timothy Bagguley and Una Macleod and Gordon Cook and Russell Patmore and Eve Roman",

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AU - Howell, Debra

AU - Smith, Alexandra

AU - Appleton, Simon

AU - Bagguley, Timothy

AU - Macleod, Una

AU - Cook, Gordon

AU - Patmore, Russell

AU - Roman, Eve

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KW - Phenotype

KW - Aged, 80 and over

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KW - Aged

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KW - Population Surveillance

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Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Abstract

Bibliographical note

Keywords

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Debra Howell

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