Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Debra Howell, Alexandra Smith, Simon Appleton, Timothy Bagguley, Una Macleod, Gordon Cook, Russell Patmore, Eve Roman

Research output: Contribution to journalArticlepeer-review


Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ 2 = 13·8, P = 0·0002).

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalBritish Journal of Haematology
Issue number1
Early online date1 Feb 2017
Publication statusPublished - 28 Mar 2017

Bibliographical note

© 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.


  • Journal Article
  • multiple myeloma
  • emergency presentation
  • route to diagnosis
  • survival
  • clinical characteristics
  • Outcome Assessment (Health Care)
  • Humans
  • Middle Aged
  • Male
  • Multiple Myeloma/diagnosis
  • United Kingdom/epidemiology
  • Phenotype
  • Aged, 80 and over
  • Female
  • Aged
  • Disease Management
  • Population Surveillance

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