Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

Timothy C. Thompson*, Jennifer Southgate, Gay Kitchener, Hartmut Land

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


ras and myc oncogenes were able to induce distinct phenotypic alterations, resembling different types of premalignant lesions, when introduced into approximately 0.1% of the cells used to reconstitute the mouse prostate gland. While ras induced dysplasia in combination with angiogenesis, myc induced a hyperplasia of the otherwise normally developed organ. ras and myc together induced primarily carcinomas. However, tumor progression was also associated with additional genetic alterations involving gene amplification. Our data indicate that specific types of benign premalignant lesions may reflect the activation of different single oncogenes, and that the consecutive activation of multiple oncogenes could be a causal event in the step-like progression of tumorigenesis.

Original languageEnglish
Pages (from-to)917-930
Number of pages14
Issue number6
Publication statusPublished - 24 Mar 1989

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