MYC regulation of cell growth through control of transcription by RNA polymerases I and III

Kirsteen J Campbell; Robert J White

doi:10.1101/cshperspect.a018408

MYC regulation of cell growth through control of transcription by RNA polymerases I and III

Kirsteen J Campbell, Robert J White

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

MYC's tumorigenic potential involves increased ribosome biogenesis and translational capacity, which supply the cell with protein required for enhanced cell growth and subsequent cell division. In addition to activation of protein-encoding genes transcribed by RNA polymerase II, MYC must stimulate transcription by RNA polymerase I and RNA polymerase III to meet this synthetic demand. In the past decade our knowledge of the mechanisms and importance of MYC regulation of RNA polymerases I and III has flourished. Here we discuss MYC's influence on transcription by these "odd" RNA polymerases and the physiological impact of this regulation is evaluated with relevance to cancer development and treatment.

Original language	English
Journal	Cold Spring Harbor perspectives in medicine
Volume	4
Issue number	5
DOIs	https://doi.org/10.1101/cshperspect.a018408
Publication status	Published - May 2014

Keywords

Basic-Leucine Zipper Transcription Factors
Carcinogenesis
Cell Proliferation
Genes, myc
Humans
RNA Polymerase I
RNA Polymerase III
RNA, Ribosomal
Ribosomes
Transcription, Genetic
Up-Regulation

Access to Document

10.1101/cshperspect.a018408

Cite this

@article{896cb448858548dd9aed9d0e37cca0bc,

title = "MYC regulation of cell growth through control of transcription by RNA polymerases I and III",

abstract = "MYC's tumorigenic potential involves increased ribosome biogenesis and translational capacity, which supply the cell with protein required for enhanced cell growth and subsequent cell division. In addition to activation of protein-encoding genes transcribed by RNA polymerase II, MYC must stimulate transcription by RNA polymerase I and RNA polymerase III to meet this synthetic demand. In the past decade our knowledge of the mechanisms and importance of MYC regulation of RNA polymerases I and III has flourished. Here we discuss MYC's influence on transcription by these {"}odd{"} RNA polymerases and the physiological impact of this regulation is evaluated with relevance to cancer development and treatment.",

keywords = "Basic-Leucine Zipper Transcription Factors, Carcinogenesis, Cell Proliferation, Genes, myc, Humans, RNA Polymerase I, RNA Polymerase III, RNA, Ribosomal, Ribosomes, Transcription, Genetic, Up-Regulation",

author = "Campbell, {Kirsteen J} and White, {Robert J}",

year = "2014",

month = may,

doi = "10.1101/cshperspect.a018408",

language = "English",

volume = "4",

journal = "Cold Spring Harbor perspectives in medicine",

issn = "2157-1422",

publisher = "Cold Spring Harbor Laboratory Press",

number = "5",

}

TY - JOUR

T1 - MYC regulation of cell growth through control of transcription by RNA polymerases I and III

AU - Campbell, Kirsteen J

AU - White, Robert J

PY - 2014/5

Y1 - 2014/5

N2 - MYC's tumorigenic potential involves increased ribosome biogenesis and translational capacity, which supply the cell with protein required for enhanced cell growth and subsequent cell division. In addition to activation of protein-encoding genes transcribed by RNA polymerase II, MYC must stimulate transcription by RNA polymerase I and RNA polymerase III to meet this synthetic demand. In the past decade our knowledge of the mechanisms and importance of MYC regulation of RNA polymerases I and III has flourished. Here we discuss MYC's influence on transcription by these "odd" RNA polymerases and the physiological impact of this regulation is evaluated with relevance to cancer development and treatment.

AB - MYC's tumorigenic potential involves increased ribosome biogenesis and translational capacity, which supply the cell with protein required for enhanced cell growth and subsequent cell division. In addition to activation of protein-encoding genes transcribed by RNA polymerase II, MYC must stimulate transcription by RNA polymerase I and RNA polymerase III to meet this synthetic demand. In the past decade our knowledge of the mechanisms and importance of MYC regulation of RNA polymerases I and III has flourished. Here we discuss MYC's influence on transcription by these "odd" RNA polymerases and the physiological impact of this regulation is evaluated with relevance to cancer development and treatment.

KW - Basic-Leucine Zipper Transcription Factors

KW - Carcinogenesis

KW - Cell Proliferation

KW - Genes, myc

KW - Humans

KW - RNA Polymerase I

KW - RNA Polymerase III

KW - RNA, Ribosomal

KW - Ribosomes

KW - Transcription, Genetic

KW - Up-Regulation

U2 - 10.1101/cshperspect.a018408

DO - 10.1101/cshperspect.a018408

M3 - Article

C2 - 24789877

SN - 2157-1422

VL - 4

JO - Cold Spring Harbor perspectives in medicine

JF - Cold Spring Harbor perspectives in medicine

IS - 5

ER -