Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

Rick M Maizels; James P Hewitson

doi:10.1128/microbiolspec.MCHD-0043-2016

Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

Rick M Maizels, James P Hewitson

Centre for Immunology and Infection

Research output: Contribution to journal › Article › peer-review

Abstract

Many major tropical diseases are caused by long-lived helminth parasites that are able to survive by modulation of the host immune system, including the innate compartment of myeloid cells. In particular, dendritic cells and macrophages show markedly altered phenotypes during parasite infections. In addition, many specialized subsets such as eosinophils and basophils expand dramatically in response to these pathogens. The changes in phenotype and function, and their effects on both immunity to infection and reactivity to bystander antigens such as allergens, are discussed.

Original language	English
Number of pages	10
Journal	Microbiology spectrum
Volume	4
Issue number	6
DOIs	https://doi.org/10.1128/microbiolspec.MCHD-0043-2016
Publication status	Published - 23 Nov 2016

Bibliographical note

Keywords

Journal Article

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10.1128/microbiolspec.MCHD-0043-2016

MCHD-0043-2016
© 2016 American Society for Microbiology. Uploaded with permission of the publisher/copyright holder. Further copying may not be permitted; contact the publisher for details
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Cite this

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