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Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

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JournalMicrobiology spectrum
DateAccepted/In press - 28 Sep 2016
DatePublished (current) - 23 Nov 2016
Issue number6
Volume4
Number of pages10
Original languageEnglish

Abstract

Many major tropical diseases are caused by long-lived helminth parasites that are able to survive by modulation of the host immune system, including the innate compartment of myeloid cells. In particular, dendritic cells and macrophages show markedly altered phenotypes during parasite infections. In addition, many specialized subsets such as eosinophils and basophils expand dramatically in response to these pathogens. The changes in phenotype and function, and their effects on both immunity to infection and reactivity to bystander antigens such as allergens, are discussed.

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© 2016 American Society for Microbiology. Uploaded with permission of the publisher/copyright holder. Further copying may not be permitted; contact the publisher for details

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