N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis

Andrew John Hunt; Thomas James Farmer; James Richard Sherwood; Helen Louise Parker; Kristof Moonen

doi:10.1039/C6GC00932H

N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis

Andrew John Hunt^*, Thomas James Farmer, James Richard Sherwood, Helen Louise Parker, Kristof Moonen

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list. Accordingly there is an urgent need for non-toxic alternatives to the dipolar aprotic solvents. N-Butylpyrrolidinone, although structurally similar to NMP, is not mutagenic or reprotoxic, yet retains many of the characteristics of a dipolar aprotic solvent. This work introduces N-butylpyrrolidinone as a new solvent for cross-coupling reactions and other syntheses typically requiring a conventional dipolar aprotic solvent.

Original language	English
Pages (from-to)	3990-3996
Number of pages	7
Journal	Green Chemistry
Volume	18
Issue number	14
Early online date	26 Apr 2016
DOIs	https://doi.org/10.1039/C6GC00932H
Publication status	Published - 21 Jul 2016

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© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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Cite this

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N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis

Abstract

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