N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

E F  Evans; N J  Lewis; I  Kapfer; G  Macdonald; R J K  Taylor

N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

E F Evans, N J Lewis, I Kapfer, G Macdonald, R J K Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

Original language	English
Pages (from-to)	1819-1825
Number of pages	7
Journal	SYNTHETIC COMMUNICATIONS
Volume	27
Issue number	11
Publication status	Published - 1997

Keywords

REMOVAL

Cite this

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title = "N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate",

abstract = "A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.",

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T1 - N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

AU - Evans, E F

AU - Lewis, N J

AU - Kapfer, I

AU - Macdonald, G

AU - Taylor, R J K

PY - 1997

Y1 - 1997

N2 - A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

AB - A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

KW - REMOVAL

M3 - Article

SN - 0039-7911

VL - 27

SP - 1819

EP - 1825

JO - SYNTHETIC COMMUNICATIONS

JF - SYNTHETIC COMMUNICATIONS

IS - 11

ER -