Neutrophils as Orchestrators in Tumor Development and Metastasis Formation

Lydia Kalafati, Ioannis Mitroulis, Panayotis Verginis, Triantafyllos Chavakis, Ioannis Kourtzelis

Research output: Contribution to journalReview articlepeer-review


Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on tumor establishment and metastasis development. We also discuss the tumor-mediated effects on granulopoiesis and neutrophil precursors in the bone marrow and the involvement of neutrophils in anti-tumor therapeutic modalities.

Original languageEnglish
Pages (from-to)581457
JournalFrontiers in Oncology
Publication statusPublished - 10 Dec 2020

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