TY - JOUR
T1 - Neutrophils as Orchestrators in Tumor Development and Metastasis Formation
AU - Kalafati, Lydia
AU - Mitroulis, Ioannis
AU - Verginis, Panayotis
AU - Chavakis, Triantafyllos
AU - Kourtzelis, Ioannis
N1 - Copyright © 2020 Kalafati, Mitroulis, Verginis, Chavakis and Kourtzelis.
PY - 2020/12/10
Y1 - 2020/12/10
N2 - Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on tumor establishment and metastasis development. We also discuss the tumor-mediated effects on granulopoiesis and neutrophil precursors in the bone marrow and the involvement of neutrophils in anti-tumor therapeutic modalities.
AB - Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on tumor establishment and metastasis development. We also discuss the tumor-mediated effects on granulopoiesis and neutrophil precursors in the bone marrow and the involvement of neutrophils in anti-tumor therapeutic modalities.
U2 - 10.3389/fonc.2020.581457
DO - 10.3389/fonc.2020.581457
M3 - Review article
C2 - 33363012
SN - 2234-943X
VL - 10
SP - 581457
JO - Frontiers in Oncology
JF - Frontiers in Oncology
ER -